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EXOG Antibody

  • 货号：
    CSB-PA007666ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA007666ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) EXOG Polyclonal antibody
  • Uniprot No.：
    Q9Y2C4
  • 基因名：
    EXOG
  • 别名：
    Endo G like 1 antibody; Endo G-like 1 antibody; Endo/exonuclease (5'-3'); endonuclease G like antibody; ENDOGL 1 antibody; ENDOGL1 antibody; ENDOGL2 antibody; Endonuclease G like 1 antibody; Endonuclease G like 2 antibody; Endonuclease G-like 1 antibody; ENGL a antibody; ENGL antibody; ENGL B antibody; ENGLA antibody; ENGLB antibody; Exog antibody; EXOG_HUMAN antibody; MGC125944 antibody; MGC125945 antibody; mitochondrial antibody; Nuclease EXOG antibody; Nuclease EXOG mitochondrial antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Nuclease EXOG, mitochondrial protein (144-368AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity.
  • 基因功能参考文献：
    1. Data suggest a role of exo/endonuclease G nuclease (hEXOG) in pathway for mitochondrial DNA repair. PMID: 28466855
    2. These data indicate that HSV-1 UL12.5 deploys cellular proteins, including ENDOG and EXOG, to destroy mtDNA and contribute to a growing body of literature highlighting roles for ENDOG and EXOG in mtDNA maintenance. PMID: 23986585
    3. EXOG depletion induces persistent SSBs in the mtDNA, enhances ROS levels, and causes apoptosis in normal cells but not in mt genome-deficient rho0 cells. PMID: 21768646
    4. ENDOGL1 is a candidate disease-susceptibility gene for type 2 diabetes in a Japanese population PMID: 17415550
    5. Human endonuclease G-like-1 is a dimeric mitochondrial enzyme that displays 5'-3' exonuclease activity and further differs from EndoG in substrate specificity PMID: 18187503

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  • 亚细胞定位：
    Mitochondrion inner membrane.
  • 蛋白家族：
    DNA/RNA non-specific endonuclease family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 3347

    OMIM: 604051

    KEGG: hsa:9941

    STRING: 9606.ENSP00000287675

    UniGene: Hs.517897