Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. F Antibody

F Antibody

  • 货号：
    CSB-PA318261LA01CCQ
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品描述：
    F polyclonal antibody CSB-PA318261LA01CCQ was produced in rabbit immunized by using the Recombinant Canine distemper virus Fusion glycoprotein F0 protein (136-608AA) as the immunogen. The target protein F is class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes.
    This Rabbit anti-Canine distemper virus (strain Onderstepoort) (CDV) F Polyclonal antibody was tested in the ELISA. The non-conjugated IgG got purified by protein G and reached up to 95% in purity. It only reacts with the F proteins of canine distemper virus-origin and may be used to detect the endogenous levels of F protein.
  • 产品名称：
    Rabbit anti-Canine distemper virus F Polyclonal antibody
  • Uniprot No.：
    P12569
  • 基因名：
    F
  • 别名：
    F antibody; Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Canine distemper virus
  • 免疫原：
    Recombinant Canine distemper virus Fusion glycoprotein F0 protein (136-608AA)
  • 免疫原种属：
    Canine distemper virus
  • 标记方式：
    Non-conjugated

    本页面中的产品，F Antibody (CSB-PA318261LA01CCQ)，的标记方式是Non-conjugated。对于F Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA318261LB01CCQ F Antibody, HRP conjugated ELISA
    FITC CSB-PA318261LC01CCQ F Antibody, FITC conjugated
    Biotin CSB-PA318261LD01CCQ F Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell membrane. The trimer of F1-F2 (F protein) probably interacts with H at the virion surface. Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes. Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis.
  • 亚细胞定位：
    Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass membrane protein.
  • 蛋白家族：
    Paramyxoviruses fusion glycoprotein family