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FAM111A Antibody

  • 货号：
    CSB-PA853484LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA853484LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA853484LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FAM111A Polyclonal antibody
  • Uniprot No.：
    Q96PZ2
  • 基因名：
    FAM111A
  • 别名：
    FAM111A antibody; KIAA1895Protein FAM111A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protein FAM111A protein (26-179AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FAM111A Antibody (CSB-PA853484LA01HU)，的标记方式是Non-conjugated。对于FAM111A Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA853484LB01HU FAM111A Antibody, HRP conjugated ELISA
    FITC CSB-PA853484LC01HU FAM111A Antibody, FITC conjugated
    Biotin CSB-PA853484LD01HU FAM111A Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Single-stranded DNA-binding serine protease that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity. DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde. Protects replication fork from stalling by removing DPCs, such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesion, or poly(ADP-ribose) polymerase 1 (PARP1)-DNA complexes trapped by PARP inhibitors. Required for PCNA loading on replication sites. Promotes S-phase entry and DNA synthesis.; (Microbial infection) May directly function at replication forks, explaining why Simian virus 40 (SV40) interacts with FAM111A to overcome host range restriction.
  • 基因功能参考文献：
    1. Together, these data suggest that FAM111A may also be important in the development and function of male genitalia. 394 PMID: 24635597
    2. study would provide evidence that FAM111A is a key molecule for normal bone development, height gain, and parathyroid hormone development and/or regulation PMID: 23996431
    3. FAM111A is a replication factor required for PCNA loading. PMID: 24561620
    4. FAM111A appears to be crucial to a pathway that governs parathyroid hormone production, calcium homeostasis, and skeletal development and growth. PMID: 23684011
    5. FAM111A functions as a host range restriction factor that is specifically targeted by SV40 large T antigen PMID: 23093934

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  • 相关疾病：
    Kenny-Caffey syndrome 2 (KCS2); Gracile bone dysplasia (GCLEB)
  • 亚细胞定位：
    Nucleus. Chromosome. Cytoplasm.
  • 蛋白家族：
    FAM111 family
  • 数据库链接：

    HGNC: 24725

    OMIM: 127000

    KEGG: hsa:63901

    UniGene: Hs.150651