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FAM129B (Ab-712) Antibody

  • 中文名称：
    FAM129B (Ab-712)兔多克隆抗体
  • 货号：
    CSB-PA998601
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from 3T3 and DU145 cells using Niban-like protein(Ab-712) antibody.
    • Immunofluorescence staining of methanol-fixed Hela cells using Niban-like protein(Ab-712) antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FAM129B Polyclonal antibody
  • Uniprot No.：
    Q96TA1
  • 基因名：
    FAM129B
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Peptide sequence around aa.710~714 (Q-V-S-S-P) derived from Human Niban-like protein.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:1000
    IF 1:100-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro.
  • 基因功能参考文献：
    1. activated EGFR phosphorylates the Y593 residue of the protein known as family with sequence similarity 129, member B (FAM129B), which is overexpressed in many types of human cancer. PMID: 26721396
    2. The rapid induction of apoptosis in FAM129B knockdown cells was reversed by co-transfection with recombinant FAM129B, indicating that its effect on apoptosis was specific. PMID: 21148485
    3. Phosphorylation of FAM129B has a role in controlling melanoma cell invasion. PMID: 19362540
  • 亚细胞定位：
    Cytoplasm, cytosol. Cell junction, adherens junction. Membrane; Lipid-anchor. Note=In exponentially growing cells, exclusively cytoplasmic. Cell membrane localization is observed when cells reach confluency and during telophase. In melanoma cells, targeting to the plasma membrane may be impaired by C-terminal phosphorylation.
  • 蛋白家族：
    Niban family
  • 数据库链接：

    HGNC: 25282

    OMIM: 614045

    KEGG: hsa:64855

    STRING: 9606.ENSP00000362409

    UniGene: Hs.522401