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FANCB Antibody

  • 货号：
    CSB-PA818751LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of PC-3 cells with CSB-PA818751LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FANCB Polyclonal antibody
  • Uniprot No.：
    Q8NB91
  • 基因名：
    FANCB
  • 别名：
    FA2 antibody; FAAP90 antibody; FAAP95 antibody; FAB antibody; FACB antibody; Fancb antibody; FANCB_HUMAN antibody; Fanconi anemia associated polypeptide of 95 kDa antibody; Fanconi anemia group B protein antibody; Fanconi anemia; complementation group B antibody; Fanconi anemia-associated polypeptide of 95 kDa antibody; Protein FACB antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Fanconi anemia group B protein (431-574AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FANCB Antibody (CSB-PA818751LA01HU)，的标记方式是Non-conjugated。对于FANCB Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA818751LB01HU FANCB Antibody, HRP conjugated ELISA
    FITC CSB-PA818751LC01HU FANCB Antibody, FITC conjugated
    Biotin CSB-PA818751LD01HU FANCB Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    DNA repair protein required for FANCD2 ubiquitination.
  • 基因功能参考文献：
    1. We identified a 9154 bp intragenic duplication in FANCB, covering the first coding exon 3 and the flanking regions. The duplicated allele gives rise to an aberrant transcript containing exon 3 duplication, predicted to introduce a stop codon in FANCB protein (p.A319*). PMID: 29193904
    2. Four single nucleotide polymorphisms were identified, three of which were located in untranslated regions of Fanconi anemia group B protein (FANCB) and predicted to be associated with normal function. PMID: 29491055
    3. Loss-of-function FANCB mutations result in a recognizable, multiple malformation phenotype in hemizygous males for which we propose clinical criteria to aid diagnosis. PMID: 21910217
    4. Inactivation of FancB may play a role in the pathogenesis of sporadic HNSCC. PMID: 20332657
    5. Elevated serum FA-2 was associated with bony metastases from breast cancer. PMID: 20465790
    6. the protein defective in individuals with Fanconi anemia belonging to complementation group B is an essential component of the nuclear protein 'core complex' responsible for monoubiquitination of FANCD2 PMID: 15502827
    7. summary of recent advances in the Fanconi anemia-BRCA network with emphasis on the new discovery of FAAP95 as the true FANCB gene [review] PMID: 15611632
    8. Mutations in FANCB are a cause of X linked VACTERL-H syndrome. PMID: 16679491
    9. Mus81 and FANCB have different roles in repair of DNA damage during replication in human cells PMID: 17903171
    10. Our results rule out a major contribution of FANCB to hereditary breast cancer. PMID: 18302019

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  • 相关疾病：
    Fanconi anemia complementation group B (FANCB)
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 3583

    OMIM: 300514

    KEGG: hsa:2187

    STRING: 9606.ENSP00000326819

    UniGene: Hs.554740