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FANK1 Antibody

  • 货号：
    CSB-PA819458HA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of MCF-7 cells with CSB-PA819458HA01HU at 1:333, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA819458HA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FANK1 Polyclonal antibody
  • Uniprot No.：
    Q8TC84
  • 基因名：
  • 别名：
    1700007B22Rik antibody; AI850911 antibody; Fank1 antibody; FANK1_HUMAN antibody; Fibronectin type 3 and ankyrin repeat domains 1 antibody; Fibronectin type 3 and ankyrin repeat domains protein 1 antibody; Fibronectin type III and ankyrin repeat domains 1 antibody; HSD13 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Fibronectin type 3 and ankyrin repeat domains protein 1 protein (1-345AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FANK1 Antibody (CSB-PA819458HA01HU)，的标记方式是Non-conjugated。对于FANK1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA819458HB01HU FANK1 Antibody, HRP conjugated ELISA
    FITC CSB-PA819458HC01HU FANK1 Antibody, FITC conjugated
    Biotin CSB-PA819458HD01HU FANK1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis.
  • 基因功能参考文献：
    1. RYBP activates FANK1-mediated activator protein 1 (AP-1) signaling pathway which contributes to tumor cell apoptosis. PMID: 27060496
    2. we find evidence for many novel candidates, the strongest of which is FANK1, an imprinted gene that suppresses apoptosis, is expressed during meiosis in males. PMID: 25144706
    3. the TNfnIII 1-5 repeats play an important role in PCO pathology. PMID: 25515583
    4. found that Jab1 (Jun activation domain-binding protein 1), a co-activator of AP-1, specifically interacted with Fank1 PMID: 20978819
    5. FANK1 may have a role in regulating gene expression in the transition from the meiotic phase to the haploid phase during spermatogenesis PMID: 17604233

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  • 亚细胞定位：
    Nucleus. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium.
  • 组织特异性：
    Mostly restricted to testis.
  • 数据库链接：

    HGNC: 23527

    OMIM: 611640

    KEGG: hsa:92565

    STRING: 9606.ENSP00000357682

    UniGene: Hs.352591