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FASTKD2 Antibody

  • 货号：
    CSB-PA002504
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COLO205 cells using FASTKD2 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9NYY8
  • 基因名：
    FASTKD2
  • 别名：
    FAKD2_HUMAN antibody; FAST kinase domain containing protein 2 antibody; FAST kinase domain-containing protein 2 antibody; FAST kinase domains 2 antibody; Fastkd2 antibody; KIAA0971 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human FASTKD2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays an important role in assembly of the mitochondrial large ribosomal subunit. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. May play a role in mitochondrial apoptosis.
  • 基因功能参考文献：
    1. Despite the fact that proteins of the FASTK family FASTKD1-5 share the same domains, they exhibit various-sometimes opposing-functions in almost all steps of mitochondrial RNA metabolism. PMID: 29036396
    2. s discovered a novel association of a polymorphism in the pro-apoptotic gene FASTKD2 (fas-activated serine/threonine kinase domains 2) with better memory performance PMID: 25385369
    3. CRISPR-mediated deletion of FASTKD2 leads to aberrant processing. PMID: 26370583
    4. Fas Activated Serine-Threonine Kinase Domains 2 (FASTKD2) mediates apoptosis of breast and prostate cancer cells through its novel FAST2 domain. PMID: 25409762
    5. regulation of FASTKD2 by NRIF3 and the DIF-1 complex acts as a novel death switch that selectively modulates apoptosis in breast cancer PMID: 21444724
    6. mutation in a gene segregating with a peculiar mitochondrial encephalomyopathy associated with COX deficiency in skeletal muscle. FASTKD2 is localized in the mitochondrial inner compartment. PMID: 18771761

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  • 亚细胞定位：
    Mitochondrion matrix, mitochondrion nucleoid. Mitochondrion matrix.
  • 蛋白家族：
    FAST kinase family
  • 组织特异性：
    Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in heart, smooth muscle and thyroid.
  • 数据库链接：

    HGNC: 29160

    OMIM: 612322

    KEGG: hsa:22868

    STRING: 9606.ENSP00000236980

    UniGene: Hs.5930