Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. FBLIM1 Antibody

FBLIM1 Antibody

  • 中文名称：
    FBLIM1多克隆抗体
  • 货号：
    CSB-PA008451GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8WUP2
  • 基因名：
    FBLIM1
  • 别名：
    2410043F08Rik antibody; Cal antibody; CSX associated LIM antibody; DKFZp434G171 antibody; FBLI1_HUMAN antibody; FBLIM 1 antibody; Fblim1 antibody; FBLP 1 antibody; FBLP-1 antibody; FBLP1 antibody; Filamin binding LIM protein 1 antibody; Filamin-binding LIM protein 1 antibody; Gt10 antibody; MGC105665 antibody; MIG2 interacting protein; antibody; MIG2-interacting protein antibody; Migfilin antibody; Mitogen inducible 2 interacting protein antibody; Mitogen-inducible 2-interacting protein antibody; OTTHUMP00000003118 antibody; OTTHUMP00000003119 antibody; OTTHUMP00000003120 antibody; OTTMUSP00000011062 antibody; OTTMUSP00000011063 antibody; RP11-169K16.5 antibody; RP23-291H3.1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human FBLIM1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion.
  • 基因功能参考文献：
    1. data implicate FBLIM1 in the pathogenesis of sterile bone inflammation and our findings suggest CRMO is a disorder of chronic inflammation and imbalanced bone remodeling PMID: 28301468
    2. the present study emphasizes for the first time to our knowledge the role of Migfilin in osteoarthritis(OA) and highlights the importance of cell-ECM adhesion proteins in OA pathogenesis. PMID: 23237804
    3. Migfilin expression is reduced in breast cancer. PMID: 23645746
    4. alpha-parvin, beta-parvin and migfilin were expressed in tumor cells in 53%, 2%, 28% and 53% of effusions and 57%, 20%, 83% and 25% of solid lesions, respectively. PMID: 23099104
    5. Migfilin positively modulates the expression and activity of epidermal growth factor receptor, and Migfilin-mediated migration and invasion depend on epidermal growth factor receptor-induced PLC-gamma and STAT3-signaling pathways. PMID: 22843679
    6. Migfilin promoted beta-catenin degradation by reinforcing the association between beta-catenin and GSK-3beta. PMID: 22246236
    7. Migfilin can activate beta1, beta2 and beta3 integrins and promote integrin mediated responses while migfilin depletion impairs the spreading and migration of endothelial cells PMID: 22043318
    8. The association between filamin B and FBLP-1 may play a hitherto unknown role in cytoskeletal function, cell adhesion, and cell motility. PMID: 12496242
    9. A review of migfilin's role as a key regulator both at cell adhesion sites and nuclei. It's possible role in the pathogenesis of several human diseases is also discussed. PMID: 15701922
    10. Migfilin has a role in interacting with vasodilator-stimulated phosphoprotein (VASP) and regulates VASP localization to cell-matrix adhesions and migration PMID: 16531412
    11. Results suggest a role for cytoplasmic migfilin in the progression of leiomyosarcomas (LMS) and identify cytoplasmic migfilin as a potentially important biological marker for human LMS progression. PMID: 17711449
    12. Loss-of-function mutations in KIND1 result in marked variability in kindlin-1 immunolabeling in Kindler syndrome skin, which is mirrored by similar changes in kindlin-2 and migfilin immunoreactivity. PMID: 18528435
    13. analysis of the migfilin-filamin interaction and competition with integrin beta 7 tails PMID: 18829455
    14. Migfilin thus acts as a molecular switch to disconnect filamin from integrin for regulating integrin activation and dynamics of extracellular matrix-actin linkage. PMID: 19074766
    15. Migfilin interacts with Src and contributes to cell-matrix adhesion-mediated survival signaling PMID: 19833732

    显示更多

    收起更多

  • 亚细胞定位：
    Cell junction, focal adhesion. Cytoplasm, cytoskeleton, stress fiber.
  • 组织特异性：
    Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets.
  • 数据库链接：

    HGNC: 24686

    OMIM: 607747

    KEGG: hsa:54751

    STRING: 9606.ENSP00000416387

    UniGene: Hs.530101