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FBLN2 Antibody

  • 货号：
    CSB-PA008453LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, U251 whole cell lysate, A549 whole cell lysate
      All lanes: FBLN2 antibody at 3.4µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 127, 132 kDa
      Observed band size: 127 kDa
    • IHC image of CSB-PA008453LA01HU diluted at 1:500 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA008453LA01HU diluted at 1:500 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FBLN2 Polyclonal antibody
  • Uniprot No.：
    P98095
  • 基因名：
    FBLN2
  • 别名：
    Fbln2 antibody; FBLN2_HUMAN antibody; FIBL-2 antibody; Fibulin-2 antibody; OTTHUMP00000216670 antibody; OTTHUMP00000216671 antibody; OTTHUMP00000216672 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Fibulin-2 protein (301-440AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FBLN2 Antibody (CSB-PA008453LA01HU)，的标记方式是Non-conjugated。对于FBLN2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA008453LB01HU FBLN2 Antibody, HRP conjugated ELISA
    FITC CSB-PA008453LC01HU FBLN2 Antibody, FITC conjugated
    Biotin CSB-PA008453LD01HU FBLN2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN.
  • 基因功能参考文献：
    1. Using in vitro approaches and cultured breast cancer cell lines s demonstrate that Fibulin-2 is a better substrate for ADAMTS-5 than it is for ADAMTS-4. Fibulin-2 degradation is associated to an enhancement of the invasive potential of T47D, MCF-7 and SK-BR-3 cells. PMID: 28099917
    2. levels of fibulin 2 dramatically increased in the retinal pigment epithelium following retinal detachment, suggesting a direct role for fibulin 2 in the re-attachment of the retina to the retinal pigment epithelium. PMID: 24692557
    3. Study identified and validated a novel bona fide target of miR-1, Fibullin-2 (Fbln2), a secreted protein implicated in extracellular matrix remodeling. PMID: 23612897
    4. Two variants in the fibulin2 gene are associated with lower systolic blood pressure and decreased risk of hypertension. PMID: 22912785
    5. Data provide evidence that FBLN2 short isoform (FBLN2S) has an important tumor-suppressive and anti-angiogenic role in nasopharyngeal carcinoma (NPC). PMID: 21743496

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Fibulin family
  • 组织特异性：
    Component of both basement membranes and other connective tissues. Expressed in heart, placenta and ovary.
  • 数据库链接：

    HGNC: 3601

    OMIM: 135821

    KEGG: hsa:2199

    STRING: 9606.ENSP00000384169

    UniGene: Hs.198862