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  4. FBXL5 Antibody

FBXL5 Antibody

  • 货号：
    CSB-PA892451ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA892451ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA892451ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FBXL5 Polyclonal antibody
  • Uniprot No.：
    Q9UKA1
  • 基因名：
    FBXL5
  • 别名：
    F box and leucine rich repeat protein 5 antibody; F box protein FBL5 antibody; F box/LRR repeat protein 5 antibody; F-box and leucine-rich repeat protein 5 antibody; F-box protein FBL4/FBL5 antibody; F-box/LRR-repeat protein 5 antibody; FBL4 antibody; FBL5 antibody; FBXL5 antibody; FBXL5_HUMAN antibody; FLR1 antibody; p45SKP2 like protein antibody; p45SKP2-like protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human F-box/LRR-repeat protein 5 protein (1-310AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.
  • 基因功能参考文献：
    1. Transcriptomic analysis shows downregulation of FBXL5 expression in HSCs of patients with myelodysplastic syndrome. PMID: 28714470
    2. regulatory circuit involving FBXL5 and CIA acts through both IRPs to control iron metabolism and promote optimal cell growth PMID: 28768766
    3. analysis of the redox sensing mechanism by which FBXL5 can serve as an iron metabolism regulator within mammalian cells PMID: 28131773
    4. FBXL5 regulates cortactin through induction of its ubiquitylation, and FBXL5 similarly regulates Snail1. PMID: 25832584
    5. FBXL5-mediated degradation of CITED2 leads to the activation of HIF-1alpha. PMID: 25956243
    6. results thus suggest that HERC2 regulates the basal turnover of FBXL5, and that this ubiquitin-dependent degradation pathway contributes to the control of mammalian iron metabolism PMID: 24778179
    7. F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis PMID: 23135277
    8. Data indicate that F-box and leucine-rich repeat protein 5 (FBXL5)-Hr (hemerythrin-like domain) undergoes substantive structural changes when iron becomes limiting, accounting for its switch-like behavior. PMID: 22648410
    9. Detailed molecular and structural characterization of the ligand-responsive hemerythrin domain provides insights into the mechanisms by which FBXL5 serves as a unique mammalian metabolic sensor. PMID: 22253436
    10. iron homeostasis is regulated by a proteolytic pathway that couples IRP2 degradation to intracellular iron levels through the stability and activity of FBXL5 PMID: 19762596
    11. observations suggest a mechanistic link between iron sensing via the FBXL5 hemerythrin domain, IRP2 regulation, and cellular responses to maintain mammalian iron homeostasis PMID: 19762597
    12. Our findings provide a potential mechanism by which p150(Glued) protein function is regulated by SCFs. PMID: 17532294

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  • 亚细胞定位：
    Cytoplasm, perinuclear region.
  • 数据库链接：

    HGNC: 13602

    OMIM: 605655

    KEGG: hsa:26234

    STRING: 9606.ENSP00000344866

    UniGene: Hs.643433