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FBXO25 Antibody

  • 货号：
    CSB-PA848401LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA848401LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA848401LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA848401LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Immunofluorescent analysis of HepG2 cells using CSB-PA848401LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FBXO25 Polyclonal antibody
  • Uniprot No.：
    Q8TCJ0
  • 基因名：
  • 别名：
    F box only protein 25 antibody; F box protein 25 antibody; F box protein Fbx25 antibody; F-box only protein 25 antibody; FBX25 antibody; FBX25_HUMAN antibody; FBXO25 antibody; MGC20256 antibody; MGC51975 antibody; OTTHUMP00000115399 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human F-box only protein 25 protein (1-291AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FBXO25 Antibody (CSB-PA848401LA01HU)，的标记方式是Non-conjugated。对于FBXO25 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA848401LB01HU FBXO25 Antibody, HRP conjugated ELISA
    FITC CSB-PA848401LC01HU FBXO25 Antibody, FITC conjugated
    Biotin CSB-PA848401LD01HU FBXO25 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT).
  • 基因功能参考文献：
    1. Taken together we show that FBXO25 functions as a negative regulator of MAPK signaling though the reduction of ERK1/2 activation. PMID: 28389297
    2. High FBXO25 expression is associated with non-small-cell lung cancer. PMID: 27596142
    3. FBXO25 functions as a haploinsufficient tumor suppressor in mantle cell lymphoma. PMID: 25419709
    4. FBXO25 mediates ELK-1 degradation through the ubiquitin proteasome system and thereby plays a role in regulating the activation of ELK-1 pathway in response to mitogens PMID: 23940030
    5. Altogether, Fbxo25 acts as an ubiquitin E3 ligase to target cardiac transcription factors including Nkx2-5, Isl1, and Hand1, indicating that cardiac protein homeostasis through Fbxo25 has a pivotal impact on cardiac development. PMID: 21596019
    6. Beta-actin, physically interacts through its N-terminus with FBXO25 and is enriched in the FBXO25 nuclear compartments. PMID: 20473970
    7. investigated hFBX25's genomic organization and established hFBX25 as an FBP by verifying its interaction with Skp1 and Cul1 PMID: 16278047
    8. The cellular distribution of FBXO25 and its colocalization with some nuclear proteins is investigated by using immunochemical and biochemical approaches. PMID: 18287534

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  • 相关疾病：
    A chromosomal aberration involving FBXO25 is a cause of X-linked mental retardation (XLMR). Translocation t(X;8)(p11.22;p23.3) with SHROOM4.
  • 亚细胞定位：
    Nucleus. Note=In the nucleus, associates with a subnuclear dot-like structure. Colocalized with SKP1.
  • 组织特异性：
    Expressed in all brain tissue observed.
  • 数据库链接：

    HGNC: 13596

    OMIM: 609098

    KEGG: hsa:26260

    STRING: 9606.ENSP00000276326

    UniGene: Hs.438454