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FBXW5 Antibody

  • 中文名称：
    FBXW5兔多克隆抗体
  • 货号：
    CSB-PA846577LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: FBXW5 antibody at 2μg/ml + PC-3 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 64, 43 kDa
      Observed band size: 64 kDa
    • Immunohistochemistry of paraffin-embedded human appendix tissue using CSB-PA846577LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA846577LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FBXW5 Polyclonal antibody
  • Uniprot No.：
    Q969U6
  • 基因名：
    FBXW5
  • 别名：
    FBXW5 antibody; FBW5 antibody; PP3971F-box/WD repeat-containing protein 5 antibody; F-box and WD-40 domain-containing protein 5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human F-box/WD repeat-containing protein 5 protein (265-494AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FBXW5 Antibody (CSB-PA846577LA01HU)，的标记方式是Non-conjugated。对于FBXW5 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA846577LB01HU FBXW5 Antibody, HRP conjugated ELISA
    FITC CSB-PA846577LC01HU FBXW5 Antibody, FITC conjugated
    Biotin CSB-PA846577LD01HU FBXW5 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway.
  • 基因功能参考文献：
    1. oxidative stress induces Tnfaip8 l1/Oxi-beta, which results in increased autophagy by its exclusive binding with FBXW5 to stabilize TSC2 PMID: 24444419
    2. DLC1 was ubiquitinated and degraded by cullin 4A-RING ubiquitin ligase (CRL4A) complex interaction with DDB1 and the FBXW5 substrate receptor. PMID: 24082123
    3. Identify Fbxw5-driven fluctuation of Eps8 levels as an important mechanism that contributes to cell-shape changes during entry into-and exit from-mitosis. PMID: 23314863
    4. Fbxw5 enhances sumoylation of nuclear c-Myb PMID: 22910413
    5. FBXW5 levels are controlled by the anaphase-promoting (APC/C) complex, which targets FBXW5 for degradation during mitosis and G1, thereby helping to reset the centrosome duplication machinery. PMID: 21725316
    6. Results indicate that FBW5-DDB1-CUL4-ROC1 is an E3 ubiquitin ligase regulating TSC2 protein stability and TSC complex turnover. PMID: 18381890
    7. These results suggest that FBXW5 negatively regulates TAK1 in the IL-1beta signaling pathway. PMID: 19232515

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    FBXW5 family
  • 数据库链接：

    HGNC: 13613

    OMIM: 609072

    KEGG: hsa:54461

    STRING: 9606.ENSP00000313034

    UniGene: Hs.522507