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FCGR2C Antibody

  • 货号：
    CSB-PA070229
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P31995
  • 基因名：
  • 别名：
    FCGR2C; CD32; FCG2; IGFR2; Low affinity immunoglobulin gamma Fc region receptor II-c; IgG Fc receptor II-c; CDw32; Fc-gamma RII-c; Fc-gamma-RIIc; FcRII-c; CD antigen CD32
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human CD32-C.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.
  • 基因功能参考文献：
    1. When higher-affinity genotypes for FCGR2A, FCGR3A, and FCGR2C were considered together, they were associated with significantly increased tumor shrinkage and prolonged survival in response to HD-IL2... this is the first study to show associations of FCGR genotypes with outcome following HD-IL2 treatment PMID: 27742794
    2. The nonclassical open reading frame in the FCGR2C gene (FCGR2C.nc-ORF) was strongly associated with a decreased alloimmunization risk (odds ratio [OR] 0.26, 95% confidence [CI] 0.11-0.64). PMID: 28899854
    3. Gene copy number variation (CNV) of the PKLR, FCGR2A, FCGR2C, and FCGR3 genes is associated with malaria severity, and our results provide evidence for a role of CNV in host responses to malaria. PMID: 28605553
    4. FCGR2A and FCGR2C polymorphisms may also contribute to immunocomplexemia present in sarcoidosis. PMID: 26801149
    5. The findings of this study highlight further ethnic variation at the FCGR gene locus, in particular for FCGR2C, a gene with increasingly recognized clinical significance. PMID: 26673965
    6. FCGR2C SNPs that associated with vaccine efficacy in RV144 also strongly associated with the expression of FCGR2A/C and one of them also associated with the expression of Fc receptor-like A (FCRLA), another Fc-gamma receptor (FcgammaR) gene PMID: 27015273
    7. These include an FCGR2A/2C chimeric gene that causes a decreased expression PMID: 26133275
    8. Data show that gains or losses in copy numbers of Fc gamma receptors FCGR3A were less frequent than for FCGR3B and FCGR2C. PMID: 26032265
    9. sequenced exons and surrounding areas of FcR-encoding genes and found one FCGR2C tag SNP (rs114945036) that associated with vaccine efficacy against HIV-1 subtype CRF01_AE, with lysine at position 169 (169K) in the V2 loop (CRF01_AE 169K) PMID: 25105367
    10. We report the discovery of allele-dependent expression of the activating FcgammaRIIc on B cells. Identical to FcgammaRIIb in the extracellular domain, FcgammaRIIc has a tyrosine-based activation motif in its cytoplasmic domain. PMID: 24353158
    11. study concludes gene copy number of FcgammaR2C and FcgammaR3B influences IVIG treatment response and predisposes individuals to Kawasaki disease, providing potential insights into understanding the mechanism of the FcgammaR gene family in the IVIG pathway PMID: 23778324
    12. Genomic pathology of SLE-associated copy-number variation at the FCGR2C/FCGR3B/FCGR2B locus.(28-40) Status: Complete Incomplete Delete PMID: 23261299
    13. Two additional variations in FcgammaRIIb/c expression on leukocytes have now been identified; findings demonstrate a more extensive and previously unnoticed variation in FcgammaR expression with relevance to immunity and inflammation. PMID: 22198951
    14. Fragment c gamma receptor gene polymorphisms is not associated with breast cancer. PMID: 20978933
    15. activating FCGR2C-ORF genotype predisposes to idiopathic thrombocytopenic purpura by altering the balance of activating and inhibitory FcgammaR on immune cells PMID: 17827395
    16. Only FCGR3A, FCGR2C and FCGR3B show copy number variation, in contrast to FCGR2A and FCGR2B. PMID: 19309690

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  • 亚细胞定位：
    [Isoform IIC4]: Cytoplasm.; [Isoform IIC3]: Cell membrane; Single-pass type I membrane protein.; [Isoform IIC2]: Cell membrane; Single-pass type I membrane protein.; [Isoform IIC1]: Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Isoform IIC1 is detected in monocytes, macrophages, polymorphonuclear cells and natural killer cells.
  • 数据库链接：

    HGNC: 15626

    OMIM: 612169

    KEGG: hsa:9103

    UniGene: Hs.654395