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FCGRT Antibody

  • 货号：
    CSB-PA851443LA01MOV
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Macaca fascicularis FCGRT Polyclonal antibody
  • Uniprot No.：
    Q8SPV9
  • 基因名：
  • 别名：
    FCGRT antibody; FCRNIgG receptor FcRn large subunit p51 antibody; FcRn antibody; IgG Fc fragment receptor transporter alpha chain antibody; Neonatal Fc receptor antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Macaca fascicularis
  • 免疫原：
    Recombinant Macaca fascicularis IgG receptor FcRn large subunit p51 protein (24-297AA)
  • 免疫原种属：
    Macaca fascicularis
  • 标记方式：
    Non-conjugated

    本页面中的产品，FCGRT Antibody (CSB-PA851443LA01MOV)，的标记方式是Non-conjugated。对于FCGRT Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA851443LB01MOV FCGRT Antibody, HRP conjugated ELISA
    FITC CSB-PA851443LC01MOV FCGRT Antibody, FITC conjugated
    Biotin CSB-PA851443LD01MOV FCGRT Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB.
  • 基因功能参考文献：
    1. None of the non-synonymous variants of FCGRT or B2M found changes in the amino acid residues known to be important for FcRn function, suggesting that substantial inter-animal variability of FcRn is not expected for the cynomolgus macaques analyzed PMID: 24806819
    2. Characterization and screening of IgG binding to the neonatal Fc receptor. PMID: 24802048
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Endosome membrane.
  • 蛋白家族：
    Immunoglobulin superfamily
  • 数据库链接：

    KEGG: mcf:102128913

    UniGene: Mfa.8387