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FCHSD2 Antibody

  • 货号：
    CSB-PA008549LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: FCHSD2 antibody at 12µg/ml
      Lane 1: U251 whole cell lysate
      Lane 2: A549 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 85, 78, 59 kDa
      Observed band size: 85 kDa
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA008549LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA008549LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FCHSD2 Polyclonal antibody
  • Uniprot No.：
    O94868
  • 基因名：
    FCHSD2
  • 别名：
    FCHSD2 antibody; KIAA0769 antibody; SH3MD3F-BAR and double SH3 domains protein 2 antibody; Carom antibody; Protein nervous wreck 1 antibody; NWK1 antibody; SH3 multiple domains protein 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human F-BAR and double SH3 domains protein 2 protein (1-290AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FCHSD2 Antibody (CSB-PA008549LA01HU)，的标记方式是Non-conjugated。对于FCHSD2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA008549LB01HU FCHSD2 Antibody, HRP conjugated ELISA
    FITC CSB-PA008549LC01HU FCHSD2 Antibody, FITC conjugated
    Biotin CSB-PA008549LD01HU FCHSD2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor. Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling. Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits. Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes.
  • 基因功能参考文献：
    1. Loss of FCHSD2 activity in nonsmall cell lung cancer (NSCLC) cells leads to increased cell-surface expression and altered signaling downstream of EGFR, resulting in enhanced cell proliferation and migration. PMID: 30249660
    2. Established 3 models of Carom-receptor complexes and their intracellular trafficking based on protein interaction and subcellular localization. Carom may mediate receptor endocytosis and transport endocytic receptors to the cytoplasm for receptor signaling and lysosome/proteasome degradation. Review. PMID: 28199211
    3. A novel SNP-systemic lupus erythematosus association was identified between FCHSD2 and P2RY2, peaking at rs11235667 on a 33-kb haplotype upstream of ATG16L2. PMID: 26663301
    4. our study, for the first time, demonstrates FCHSD2 as a predictor of outcome for Acute myeloid leukemia patients PMID: 22902056
  • 亚细胞定位：
    Cytoplasm. Cell junction. Membrane, clathrin-coated pit. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, stereocilium.
  • 组织特异性：
    Liver, brain, heart, placenta, skeletal muscle, pancreas, lung and kidney.
  • 数据库链接：

    HGNC: 29114

    OMIM: 617556

    KEGG: hsa:9873

    STRING: 9606.ENSP00000386722

    UniGene: Hs.744959