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FDXR Antibody

  • 货号：
    CSB-PA008575LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: FDXR antibody at 6µg/ml
      Lane 1: A549 whole cell lysate
      Lane 2: Mouse liver tissue
      Lane 3: HepG2 whole cell lysate
      Lane 4: U251 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 54, 55, 59, 49, 53, 50, 58 kDa
      Observed band size: 54 kDa
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA008575LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FDXR Polyclonal antibody
  • Uniprot No.：
    P22570
  • 基因名：
    FDXR
  • 别名：
    Adrenodoxin reductase antibody; ADRO_HUMAN antibody; ADXR antibody; AR antibody; FDXR antibody; Ferredoxin NADP(+) reductase antibody; Ferredoxin reductase antibody; Ferredoxin--NADP(+) reductase antibody; mitochondrial antibody; NADPH adrenodoxin oxidoreductase mitochondrial antibody; NADPH:adrenodoxin oxidoreductase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human NADPH:adrenodoxin oxidoreductase, mitochondrial protein (33-451AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FDXR Antibody (CSB-PA008575LA01HU)，的标记方式是Non-conjugated。对于FDXR Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA008575LB01HU FDXR Antibody, HRP conjugated ELISA
    FITC CSB-PA008575LC01HU FDXR Antibody, FITC conjugated
    Biotin CSB-PA008575LD01HU FDXR Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
  • 基因功能参考文献：
    1. These data provide further insight into the pathogenic mechanism of FDXR-mediated central neuropathy, and suggest an avenue for mechanistic studies that will ultimately inform treatment. PMID: 30250212
    2. we identified a novel disease-causing gene FDXR associated with mitochondrial diseases. The biallelic FDXR mutations cause optic atrophy and neuropathy. we found that FDXR levels are significantly lower in the patient fibroblast cells with the homozygous mutations R392W. Fourteen missense or nonsense FDXR mutations were identified in this study and eight of them (I143F, V158M, T211A, I213F, K280*, R315*, C359Y, D374N) clu PMID: 29040572
    3. Using surface plasmon resonance, physiologically relevant concentrations of isatin (25-100 muM) were found to increase affinity of interactions between human recombinant ferrochelatase (FECH) and NADPH-dependent adrenodoxin reductase (ADR). PMID: 28905435
    4. Mutation in FDXR gene is associated with Sensorial Neuropathies. PMID: 28965846
    5. NOS-3 overexpression resulted in an increased sensitivity to anti-Fas induced cell death, independently of AR expression and CatD activity. PMID: 25712867
    6. These results indicated that abundant FDXR expression in these steroidogenic cells was maintained through SF-1 binding to the intronic enhancer of the FDXR gene PMID: 24321386
    7. results suggest that both FDX1 and FDX2 and their likely reductase partner, FDXR, contribute to iron-sulfur cluster biogenesis PMID: 22101253
    8. comparison of catalytic properties between conditions of limiting and saturating adrenodoxin reductase [cytochrome P450scc] PMID: 12137805
    9. The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis PMID: 12370809
    10. ADXR rate of hydroxylation was linear with incubation time. PMID: 12782149

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  • 亚细胞定位：
    Mitochondrion inner membrane; Peripheral membrane protein.
  • 蛋白家族：
    Ferredoxin--NADP reductase type 1 family
  • 数据库链接：

    HGNC: 3642

    OMIM: 103270

    KEGG: hsa:2232

    STRING: 9606.ENSP00000462972

    UniGene: Hs.69745