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FEM1A Antibody

  • 中文名称：
    FEM1A兔多克隆抗体
  • 货号：
    CSB-PA259482
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA259482(FEM1A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA259482(FEM1A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9BSK4
  • 基因名：
    FEM1A
  • 别名：
    AW611390 antibody; DKFZp762M136 antibody; EPRAP antibody; Fem-1 homolog a (C. elegans) antibody; Fem1 homolog a antibody; FEM1-alpha antibody; FEM1-alpha-A antibody; FEM1a antibody; FEM1a-A antibody; FEM1A_HUMAN antibody; Fem1aa antibody; Feminization 1 homolog a (C. elegans) antibody; Feminization 1 homolog a antibody; MGC114562 antibody; MGC117925 antibody; Prostaglandin E receptor 4-associated protein antibody; Protein fem-1 homolog A antibody; Protein fem-1 homolog A-A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human FEM1A
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. Promotes ubiquitination and degradation of SLBP. Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4. Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling.
  • 基因功能参考文献：
    1. FEM1 proteins are ancient regulators of Stem-Loop Binding Protein. PMID: 28118078
    2. Particular genotypes of the rs12460989 and rs8111933 loci of FEM1A gene are associated with PCOS in Chinese Han. PMID: 22678803
    3. Fem1a downregulation may be involved in, and/or a marker of, an early cell fate defect fundamental to rhabdomyosarcoma pathogenesis PMID: 16254458
    4. PGE(2)-EP4 signaling augments NF-kappaB1 p105 protein stability through EPRAP after proinflammatory stimulation, limiting macrophage activation. PMID: 18270204
    5. This study presents evidence suggesting a role for FEM1A and FEM1B in the pathogenesis of polycystic ovary syndrome. PMID: 18757445

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  • 亚细胞定位：
    Mitochondrion. Cytoplasm.
  • 蛋白家族：
    Fem-1 family
  • 组织特异性：
    Present in macrophages derived from peripheral blood monocytes. Also present in atheromata (at protein level).
  • 数据库链接：

    HGNC: 16934

    OMIM: 613538

    KEGG: hsa:55527

    STRING: 9606.ENSP00000269856

    UniGene: Hs.515082