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FGF11 Antibody

  • 货号：
    CSB-PA006109
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of NIH-3T3 Hela cells using FGF-11 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q92914
  • 基因名：
    FGF11
  • 别名：
    FGF 11 antibody; FGF-11 antibody; FGF11 antibody; FGF11_HUMAN antibody; FHF 3 antibody; FHF-3 antibody; FHF3 antibody; Fibroblast growth factor 11 antibody; Fibroblast growth factor homologous factor 3 antibody; FLJ16061 antibody; MGC102953 antibody; MGC45269 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human FGF-11.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probably involved in nervous system development and function.
  • 基因功能参考文献：
    1. Endothelial miR-342-3p expression was significantly compromised in T2DM organisms and this inhibition powerfully blocked vasculogenesis in vivo by repressing endothelial proliferation and migration. From a mechanistic standpoint, miR-342-3p promoted the transactivation of fibroblast growth factor 11 (FGF11) by directly targeting its 3' untranslated regions (3'UTRs). PMID: 29852165
    2. FGF11 as a novel factor driving pathological bone resorption in osteolytic disease and as a potential target for the development of new anti-resorptive therapeutic agents PMID: 28097375
    3. Exosomal miR-24-3p is involved in tumour pathogenesis by mediating T-cell suppression via repression of FGF11, and may serve as a potential prognostic biomarker in nasopharyngeal carcinoma (NPC). PMID: 27538493
    4. these results suggest a cross-regulation between HIF-1alpha and FGF11, through which hypoxia-induced FGF11 reinforces hypoxia responses by enhancing the stability of HIF-1alpha. PMID: 28027390
    5. Study found that FGF11 expression can be induced through HIF-1 binding sites in its promoter region suggesting that FGF11 acts as a novel modulator of hypoxia-induced pathological processes such as tumor progression. PMID: 26323829
    6. these results concluded that infiltrating CD4(+) T cells could promote PCa metastasis via modulation of FGF11-->miRNA-541-->AR-->MMP9 signaling. PMID: 25135278

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  • 蛋白家族：
    Heparin-binding growth factors family
  • 组织特异性：
    Nervous system.
  • 数据库链接：

    HGNC: 3667

    OMIM: 601514

    KEGG: hsa:2256

    STRING: 9606.ENSP00000293829

    UniGene: Hs.655193