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FGL1 Antibody

  • 货号：
    CSB-PA004850
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of mouse liver cells using Hepassocin Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q08830
  • 基因名：
    FGL1
  • 别名：
    FGL 1 antibody; Fgl1 antibody; FGL1_HUMAN antibody; Fibrinogen like 1 antibody; Fibrinogen like protein 1 antibody; Fibrinogen related protein 1 antibody; Fibrinogen-like protein 1 antibody; Hepassocin antibody; Hepatocellular carcinoma related sequence antibody; Hepatocyte derived fibrinogen related protein 1 antibody; Hepatocyte-derived fibrinogen-related protein 1 antibody; HFREP 1 antibody; HFREP-1 antibody; HFREP1 antibody; HP 041 antibody; HP-041 antibody; HP041 antibody; LFIRE 1 antibody; LFIRE-1 antibody; LFIRE1 antibody; Liver fibrinogen related protein 1 antibody; Liver fibrinogen-related protein 1 antibody; MFIRE 1 antibody; MGC108569 antibody; MGC12455 antibody; MGC37822 antibody; OTTHUMP00000122468 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Hepassocin.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3. Responsible for LAG3 T-cell inhibitory function. Binds LAG3 independently from MHC class II (MHC-II). Secreted by, and promotes growth of, hepatocytes.
  • 基因功能参考文献：
    1. FGL1 promotes invasion and metastasis of gastric cancer and is associated with poor prognosis. PMID: 29845203
    2. findings highlight the crucial role of HFREP1 in insulin resistance and diabetes, and provide a potential strategy and biomarker for developing therapeutic approaches to combat these diseases. PMID: 27221093
    3. Hepassocin plays an important role in non-alcoholic fatty liver disease and induces hepatic lipid accumulation through an ERK1/2-dependent pathway. PMID: 23792031
    4. Here, the application of small ubiquitin-related modifier (SUMO) fusion technology in combination with four different chaperone teams on the soluble expression of recombinant HPS protein was explored and analyzed. PMID: 24084006
    5. Findings suggest that hepassocin promotes hepatic cell line L02 cells proliferation via an autocrine mechanism and inhibits HCC cells proliferation by an intracrine pathway. PMID: 21618590
    6. data demonstrated that liver-specific gene LFIRE-1/HFREP-1 was frequently downregulated and might possess growth suppressor activity in HCC PMID: 14981537
    7. HFREP-1 in plasma almost completely bound to the fibrin matrix during clot formation PMID: 16996032
    8. The enhancement of FGL1 levels in vitro by IL-6 and its induction after turpentine oil injection suggest that it is an acute phase reactant. PMID: 18039467
    9. HNF1 binding site and HNF1alpha are critical to liver-specific expression of HPS, and down-regulation or loss of HNF1alpha causes, at least in part, the transcriptional down-regulation of HPS in HCC. PMID: 19304666

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Under normal conditions, liver-specific.
  • 数据库链接：

    HGNC: 3695

    OMIM: 605776

    KEGG: hsa:2267

    STRING: 9606.ENSP00000221204

    UniGene: Hs.491143