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FIGN Antibody

  • 货号：
    CSB-PA008676LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA008676LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA008676LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate, Mouse brain tissue
      All lanes: FIGN antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 83 kDa
      Observed band size: 83, 38 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FIGN Polyclonal antibody
  • Uniprot No.：
    Q5HY92
  • 基因名：
    FIGN
  • 别名：
    FIGNFidgetin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Fidgetin protein (132-371AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FIGN Antibody (CSB-PA008676LA01HU)，的标记方式是Non-conjugated。对于FIGN Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA008676LB01HU FIGN Antibody, HRP conjugated ELISA
    FITC CSB-PA008676LC01HU FIGN Antibody, FITC conjugated
    Biotin CSB-PA008676LD01HU FIGN Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:2000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome.
  • 基因功能参考文献：
    1. FIGN might play an important role in decreased congenital heart defect risk by upregulating plasma folate concentration during embryo heart development PMID: 28534241
    2. FIGN +94762G>C polymorphism reduced the risk of congenital heart defects by activating the transcription of an alternative FIGN isoform, inhibiting proteasome activity and allowing the accumulation of RFC1 and DHFR, promoting folate transmembrane transport and utilization. PMID: 28302752
    3. The loss of Fidgetin induces a microtubule-dependent enlargement of mitotic centrosomes and an increase in the number and length of astral microtubules. PMID: 22672901
  • 亚细胞定位：
    Nucleus matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to centrosomes throughout mitosis and to the spindle midzone during telophase.
  • 蛋白家族：
    AAA ATPase family
  • 数据库链接：

    HGNC: 13285

    OMIM: 605295

    KEGG: hsa:55137

    STRING: 9606.ENSP00000333836

    UniGene: Hs.593650