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FKBP6 Antibody

  • 货号：
    CSB-PA008702LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA008702LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA008702LA01HU at dilution of 1:100
    • Immunofluorescent analysis of MCF-7 cells using CSB-PA008702LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: HEK293 whole cell lysate
      All lanes: FKBP6 antibody at 4µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 38, 37, 34 kDa
      Observed band size: 38 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FKBP6 Polyclonal antibody
  • Uniprot No.：
    O75344
  • 基因名：
    FKBP6
  • 别名：
    36 kDa FK506 binding protein antibody; 36 kDa FK506-binding protein antibody; 36 kDa FKBP antibody; EC 5.2.1.8 antibody; FK506 binding protein 6 antibody; FK506-binding protein 6 antibody; FKBP 36 antibody; FKBP-36 antibody; FKBP-6 antibody; FKBP36 antibody; fkbp6 antibody; FKBP6_HUMAN antibody; Immunophilin FKBP36 antibody; Peptidyl prolyl cis trans isomerase antibody; Peptidyl-prolyl cis-trans isomerase FKBP6 antibody; PPIase antibody; PPIase FKBP6 antibody; Rotamase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Inactive peptidyl-prolyl cis-trans isomerase FKBP6 protein (101-327AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FKBP6 Antibody (CSB-PA008702LA01HU)，的标记方式是Non-conjugated。对于FKBP6 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA008702LB01HU FKBP6 Antibody, HRP conjugated ELISA
    FITC CSB-PA008702LC01HU FKBP6 Antibody, FITC conjugated
    Biotin CSB-PA008702LD01HU FKBP6 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes.
  • 基因功能参考文献：
    1. Genome wide DNA methylation assessment approach identified novel biomarkers that differentiate between cervical cancer and normal samples. In the Validation cohort FKBP6 promoter methylation had 73% sensitivity and 80% specificity (AUC = 0.80). PMID: 24241165
    2. 278A polymorphism of FKBP6 gene was associated with idiopathic azoospermia, while C/T, 370G/A, 430G/C, 467T/C, 468G/A polymorphisms might be very rare in Chinese population. PMID: 15696470
    3. may play a role in modifying the susceptibility to idiopathic spermatogenic impairment in human; allele A of c.216C>A seems to be a protective factor for the development of male infertility PMID: 17307919
    4. clathrin-FKBP36-Hsp72 complexes resulting from both identified interactions are bound to the matrices of clathrin-coated vesicles in spermatocytes, which indicates a possible role of FKBP36 and Hsp72 in the disassembly of clathrin coats PMID: 18529014
    5. FKBP36 diminishes GAPDH activity by direct interaction and down-regulation of GAPDH PMID: 19001379

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  • 相关疾病：
    FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease (PubMed:9782077). A father and son with Williams-Beuren syndrome appear to have a common heterozygous deletion that includes FKBP6 gene. However, the haploinsufficiency for FKBP6 does not appear to preclude male fertility (PubMed:15770126).
  • 亚细胞定位：
    Cytoplasm, cytosol. Nucleus. Chromosome.
  • 蛋白家族：
    FKBP6 family
  • 组织特异性：
    Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney.
  • 数据库链接：

    HGNC: 3722

    OMIM: 604839

    KEGG: hsa:8468

    STRING: 9606.ENSP00000252037

    UniGene: Hs.661266