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FLRT3 Antibody

  • 货号：
    CSB-PA882162LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: DARS2 antibody at 16μg/ml
      Lane 1: Mouse heart tissue
      Lane 2: Mouse liver tissue
      Lane 3: Mouse brain tissue
      Lane 4: Mouse skeletal muscle tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 73 kDa
      Observed band size: 73 kDa
    • Immunofluorescent analysis of HepG2 cells using CSB-PA882162LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品描述：

    The FLRT3 antibody is a high-quality polyclonal antibody suitable for the detection of the FLRT3 protein from human and mouse samples. It is available as the unconjugated IgG isoform. This FLRT3 antibody is raised in the rabbit against a partial recombinant protein mapping within amino acids 209-264 of human FLRT3. This FLRT3 antibody is purified by protein G affinity chromatography with a purity of up to 95%. And it has been validated for use in ELISA, WB, and IF applications.

    Its target protein FLRT3 plays important roles in various cellular processes such as axon guidance, cell migration, and synapse formation during development. FLRT3 is predominantly expressed in the nervous system and is involved in the formation and maintenance of neural circuits.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FLRT3 Polyclonal antibody
  • Uniprot No.：
    Q9NZU0
  • 基因名：
    FLRT3
  • 别名：
    fibronectin leucine rich transmembrane protein 3 antibody; Fibronectin-like domain-containing leucine-rich transmembrane protein 3 antibody; FLRT 3 antibody; FLRT3 antibody; FLRT3_HUMAN antibody; KIAA1469 antibody; Leucine-rich repeat transmembrane protein FLRT3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Leucine-rich repeat transmembrane protein FLRT3 protein (209-264AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FLRT3 Antibody (CSB-PA882162LA01HU)，的标记方式是Non-conjugated。对于FLRT3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA882162LB01HU FLRT3 Antibody, HRP conjugated ELISA
    FITC CSB-PA882162LC01HU FLRT3 Antibody, FITC conjugated
    Biotin CSB-PA882162LD01HU FLRT3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina. Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members. Promotes neurite outgrowth (in vitro). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development.
  • 基因功能参考文献：
    1. Low FLRT3 expression is associated with lung graft dysfunction. PMID: 27421969
  • 相关疾病：
    Hypogonadotropic hypogonadism 21 with or without anosmia (HH21)
  • 亚细胞定位：
    Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane. Cell junction, focal adhesion. Secreted. Cell projection, axon. Cell projection, growth cone membrane.
  • 组织特异性：
    Expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart.
  • 数据库链接：

    HGNC: 3762

    OMIM: 604808

    KEGG: hsa:23767

    STRING: 9606.ENSP00000339912

    UniGene: Hs.41296