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  4. FMNL2 Antibody

FMNL2 Antibody

  • 货号：
    CSB-PA008744GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q96PY5
  • 基因名：
    FMNL2
  • 别名：
    FMNL2 antibody; FHOD2 antibody; KIAA1902Formin-like protein 2 antibody; Formin homology 2 domain-containing protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human FMNL2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics.
  • 基因功能参考文献：
    1. FMNL2 knockout cells were characterized by impaired filopodia formation similar to depletion of the Rho GTPase Cdc42. PMID: 29579104
    2. Data demonstrate that the FMNL2/COMMD10/p65 NF kappaB axis acts as a critical regulator in the maintenance of metastatic phenotypes in colorectal cancer. PMID: 28817833
    3. Our data proved that RMRP acted as an oncogene LncRNA to promote the expression of KRAS, FMNL2 and SOX9 by inhibiting miR-206 expression in lung cancer. These data suggested that RMRP might serve as a therapeutic target in lung adenocarcinoma PMID: 27906963
    4. FMNL2 is likely to be generally required in melanoma cells for invasion. PMID: 27578625
    5. miR-206 functioned as a tumor suppressor in the progression of colorectal cancer(CRC) by targeting FMNL2 and c-MET. Restoration of miR-206 expression may represent a promising therapeutic approach for targeting malignant CRC. PMID: 26515696
    6. Capping protein and FMNL2 functionally coregulate filament barbed-end assembly. PMID: 26564775
    7. The two interacting FMNL-Cdc42 heterodimers expose six membrane interaction motifs on a convex protein surface, the assembly of which may facilitate actin filament elongation at the leading edge of lamellipodia and filopodia. PMID: 25963737
    8. These data establish a role for FMNL2 in the regulation of beta1-integrin and provide a mechanistic understanding of the function of FMNL2 in cancer invasiveness. PMID: 26256210
    9. MiR-34a was down-regulated in colorectal cancer cells and inversely correlated with FMNL2 and E2F5 expressions. Our study suggests that miR-34a is an important tumor suppressor of CRC progression by targeting FMNL2 and E2F5. PMID: 26103003
    10. Rac1-induced actin assembly and subsequent AJ formation critically depends on FMNL2. PMID: 25963818
    11. miR-137, induced by its upstream transcription factor HMGA1, can suppress colorectal cancer cell invasion and metastasis by targeting FMNL2. PMID: 23201162
    12. FMNL2 is a novel elongation factor of actin filaments that constitutes the first Cdc42 effector promoting cell migration and actin polymerization at the tips of lamellipodia. PMID: 22608513
    13. formin-like 2 expression correlated positively with tumor differentiation (P = .046) and vascular invasion (P = .008). Patients whose tumors had lower formin-like 2 expression had shorter overall survival times PMID: 21496865
    14. Findings identify a novel EMT and tumor promoting function for FMNL2, which is involved in TGF-beta-induced EMT and colorectal carcinoma cell invasion via Smad3 effectors, or in collaboration with MAPK/MEK pathway. PMID: 21071512
    15. a novel regulatory and functional interaction between RhoC and FMNL2 for modulating cell shape and invasiveness and provide mechanistic insight into RhoC-specific signalling events. PMID: 20101212
    16. FMNL2 may play an important role in the metastasis of CRC and may be a useful marker for metastasis of CRC. PMID: 18665374

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Formin homology family
  • 数据库链接：

    HGNC: 18267

    OMIM: 616285

    KEGG: hsa:114793

    STRING: 9606.ENSP00000288670

    UniGene: Hs.654630