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FMO1 Antibody

  • 货号：
    CSB-PA008746ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA008746ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA008746ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FMO1 Polyclonal antibody
  • Uniprot No.：
    Q01740
  • 基因名：
    FMO1
  • 别名：
    Dimethylaniline monooxygenase [N oxide forming] 1 antibody; Dimethylaniline monooxygenase [N-oxide-forming] 1 antibody; Dimethylaniline oxidase 1 antibody; Fetal hepatic flavin containing monooxygenase 1 antibody; Fetal hepatic flavin-containing monooxygenase 1 antibody; Flavin containing monooxygenase 1 (fetal liver) antibody; Flavin Containing Monooxygenase 1 antibody; FMO 1 antibody; FMO1 antibody; FMO1_HUMAN antibody; OTTHUMP00000033536 antibody; OTTHUMP00000033537 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Dimethylaniline monooxygenase [N-oxide-forming] 1 protein (363-532AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.
  • 基因功能参考文献：
    1. Report developmental regulation of hepatic FMO1 expression. PMID: 26839369
    2. Study tested the genetic effects of three FMOs genes (FMO1, FMO3, and FMO6P) on nicotine dependence by performing targeted sequencing on 2,852 nicotine-dependent and nondependent smokers; identified significant association signals for gene FMO1 and FMO6P PMID: 28413702
    3. data support the role of FMO3 in the N-oxidation of OLA and implicate for the first time the contribution of FMO1 and its functional *6 variant in OLA disposition PMID: 23147717
    4. polymorphisms in FMO1 are significant risk factors in the development of nicotine dependence and that the mechanism may involve variation in nicotine pharmacology. PMID: 21540762
    5. The results of this study suggested that the alteration of FMO gene expression is a consequence of the pathological environment linked to oxidative stress related to mutated SOD1. PMID: 21082301
    6. FMO1 expression is restricted to the fetus; FMO1 suppression occurred within 3 d postpartum in a process tightly coupled to birth, but not gestational age. PMID: 11809920
    7. data from transient expression assays in HepG2 cells suggested this SNP could account for a 2- to 3-fold loss of FMO1 promoter activity. PMID: 12829732
    8. ...in fetal liver, where FMO1 predominates attaining expression levels of (about) 32% of expressed CYP3A4. p. 574 "...recent examples indicate that FMOs play a prominent role in the metabolism ...of important drugs." p. 575 PMID: 15203093
    9. FMO1 was found to be down-regulated in human adult brain tissue. PMID: 16183778
    10. Early studies described in this review document that FMO1 is the most abundant FMO enzyme in the human fetal liver, whereas FMO3 is essentially absent. PMID: 16863467
    11. Specific allelic variants of the FMO1 gene might be associated to susceptibility to develop ALS. PMID: 17127561
    12. The resulting data showed that N,N-dimethylamphetamine N-oxidation is mainly mediated by FMO1. PMID: 19552509

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  • 亚细胞定位：
    Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族：
    FMO family
  • 组织特异性：
    Expressed mainly in fetal and adult liver.
  • 数据库链接：

    HGNC: 3769

    OMIM: 136130

    KEGG: hsa:2326

    STRING: 9606.ENSP00000346901

    UniGene: Hs.1424