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FMO5 Antibody

  • 货号：
    CSB-PA008751ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA008751ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FMO5 Polyclonal antibody
  • Uniprot No.：
    P49326
  • 基因名：
    FMO5
  • 别名：
    Dimethylaniline monooxygenase [N oxide forming] 5 antibody; Dimethylaniline monooxygenase [N-oxide-forming] 5 antibody; Dimethylaniline oxidase 5 antibody; FMO 5 antibody; FMO5 antibody; FMO5_HUMAN antibody; Hepatic flavin containing monooxygenase 5 antibody; Hepatic flavin-containing monooxygenase 5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Dimethylaniline monooxygenase [N-oxide-forming] 5 protein (1-285AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (Probable). Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.
  • 基因功能参考文献：
    1. Report relatively stable FMO5 expression throughout development. PMID: 26839369
    2. Nabumetone and pentoxifylline, two widely used pharmaceuticals, were thereby demonstrated to be efficiently oxidized in vitro by FMO5 to the corresponding acetate esters with high selectivity. PMID: 28783300
    3. absence of the typical characteristic sequence motifs sets human FMO5 apart from all characterized Baeyer-Villiger mono-oxygenases so far. These findings open new perspectives in human oxidative metabolism PMID: 26771671
    4. fmo5 displayed a significant, dominant liver-specific mRNA profile. PMID: 16183778
  • 亚细胞定位：
    Microsome membrane. Endoplasmic reticulum membrane.
  • 蛋白家族：
    FMO family
  • 组织特异性：
    Expressed in fetal and adult liver.
  • 数据库链接：

    HGNC: 3773

    OMIM: 603957

    KEGG: hsa:2330

    STRING: 9606.ENSP00000254090

    UniGene: Hs.642706