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FMOD Antibody

  • 货号：
    CSB-PA008755LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: A549 whole cell lysate, MCF-7 whole cell lysate, Rat liver tissue
      All lanes: FMOD antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 44 kDa
      Observed band size: 44 kDa
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA008755LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA008755LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FMOD Polyclonal antibody
  • Uniprot No.：
    Q06828
  • 基因名：
    FMOD
  • 别名：
    Collagen binding 59 kDa protein antibody; Collagen-binding 59 kDa protein antibody; Fibromodulin antibody; Fibromodulin precursor antibody; Fibromodulin proteoglycan antibody; FM antibody; FMOD antibody; FMOD_HUMAN antibody; Keratan sulfate proteoglycan fibromodulin antibody; KSPG fibromodulin antibody; SLRR2E antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Fibromodulin protein (18-89AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FMOD Antibody (CSB-PA008755LA01HU)，的标记方式是Non-conjugated。对于FMOD Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA008755LB01HU FMOD Antibody, HRP conjugated ELISA
    FITC CSB-PA008755LC01HU FMOD Antibody, FITC conjugated
    Biotin CSB-PA008755LD01HU FMOD Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.
  • 基因功能参考文献：
    1. The results of luciferase reporter assay and methylation-specific PCR (MSP) demonstrated that GDNF facilitated the demethylation of the FMOD promoter. PMID: 30176167
    2. crystal structures at ~2.2A resolution of human fibromodulin and chondroadherin. PMID: 28215822
    3. we found that secreted FMOD as an important regulator of glioma cell migration downstream of TGF-beta1 pathway and forms a potential basis for therapeutic intervention in GBM. PMID: 27212030
    4. The small leucine rich proteoglycan fibromodulin is overexpressed in human prostate epithelial cancer cell lines in culture and human prostate cancer tissue. PMID: 26600400
    5. expression levels distinguish chronic lymphocytic leukemia B cells from normal B lymphocytes PMID: 26318878
    6. The data suggest a fibromodulin-modulated collagen cross-linking mechanism where fibromodulin binds to a specific part of the collagen domain and also forms a complex with lysyl oxidase, targeting the enzyme toward specific cross-linking sites. PMID: 26893379
    7. fibromodulin is involved in the inflammatory processes that characterize atherosclerotic plaque vulnerability PMID: 26125412
    8. The results suggest that regions within FMOD is associated with ACL injury susceptibility and that genetic sequence variability within genes encoding proteoglycans may potentially modulate the ligament fibril properties. PMID: 24552666
    9. Melanocyte-secreted factor FMOD is a key regulator of angiogenesis. PMID: 24355922
    10. Associations between higher fibomodulin gene expression and risk factors in chronic lymphocytic leukemia. PMID: 22099931
    11. Hepatic fibromodulin activates hepatic stellate cells and promotes collagen I deposition, which leads to liver fibrosis. PMID: 22138190
    12. lumican and fibromodulin display different behaviors and that lumican may promote regeneration of the TMJ after degeneration and deformation induced by IL-1 beta. PMID: 22073367
    13. study shows (1) a detailed description of ectopic ossification (EO) formed by Bgn, Fmod or combined depletion, (2) the role of exercise in modulating EO and (3) that Bgn and Fmod are critical in controlling motor function. PMID: 19422643
    14. Fibromodulin is shown for the first time to be naturally processed and presented as a tumor-associated antigen in primary chronic lymphocytic leukemia cells, enabling the expansion of autologous tumor-specific T cells. PMID: 15471955
    15. Fibromodulin has a role in progression of B-cell chronic lymphocytic leukemia and mantle cell lymphoma PMID: 15741214
    16. fibromodulin activates the classical pathway of complement by directly binding C1q PMID: 16046396
    17. complement control protein 6-8 is able to interact with DNA and necrotic cells, but in contrast the His-384 allotype binds these ligands more strongly than the Tyr-384 variant PMID: 17293598
    18. The collagen-binding Glu-353 and Lys-355 residues in fibromodulin are exposed on the exterior of the beta-sheet-loop structure of the leucine-rich repeat, which resembles the location of interacting residues in other leucine-rich repeat proteins. PMID: 17623650
    19. Fibromodulin gene is constantly expressed in human epidermal keratinocytes. PMID: 18448071
    20. Specific decorin and fibromodulin core protein fragments in degenerate meniscus and/or human articular cartilage may be of value as biomarkers of disease. PMID: 18620607
    21. CD200 blockade was further shown to stimulate antigen-specific T cell responses towards the CLL-associated antigen fibromodulin PMID: 18838168
    22. Homologous sequence in lumican and fibromodulin leucine-rich repeat 5-7 competes for collagen binding. PMID: 19008226
    23. Ultraviolet B and A irradiation induce FMOD expression in fibroblasts in vitro. PMID: 19041686
    24. differentially expressed in mesenchymal stromal cell subset with reduced differentiation potential PMID: 19242838
    25. tyrosine sulfate-rich domains of the LRR proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of heparin-binding proteins, including bioactive factors PMID: 19700767

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Small leucine-rich proteoglycan (SLRP) family, SLRP class II subfamily
  • 数据库链接：

    HGNC: 3774

    OMIM: 600245

    KEGG: hsa:2331

    STRING: 9606.ENSP00000347041

    UniGene: Hs.519168