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FNTA Antibody

  • 货号：
    CSB-PA064938
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA064938(FNTA Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA064938(FNTA Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P49354
  • 基因名：
    FNTA
  • 别名：
    CAAX farnesyltransferase alpha subunit antibody; CAAX farnesyltransferase subunit alpha antibody; EC 2.5.1.58 antibody; EC 2.5.1.59 antibody; Farnesyl protein transferase alpha subunit antibody; Farnesyltransferase CAAX box alpha antibody; Farnesyltransferase; CAAX box; alpha antibody; Fnta antibody; FNTA_HUMAN antibody; FPTA antibody; FTase alpha antibody; FTase-alpha antibody; GGTase I alpha antibody; GGTase-I-alpha antibody; MGC99680 antibody; OTTHUMP00000229206 antibody; OTTHUMP00000229262 antibody; PGGT1A antibody; Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit antibody; Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha antibody; Protein prenyltransferase alpha subunit repeat containing 2 antibody; PTAR2 antibody; Ras proteins prenyltransferase alpha antibody; Ras proteins prenyltransferase subunit alpha antibody; Type I protein geranyl geranyltransferase alpha subunit antibody; Type I protein geranyl-geranyltransferase subunit alpha antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Fusion protein of Human FNTA
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.
  • 基因功能参考文献：
    1. These findings collectively suggest that the combination of farnesyltransferase inhibitors and gamma-secretase inhibitors is a promising therapeutic strategy for glioblastoma through selectively targeting the cancer stem cell subpopulation. PMID: 29198824
    2. Exploring the putative self-binding property of the human farnesyltransferase alpha-subunit PMID: 28948621
    3. our findings identify Geranylgeranyl transferase 1 as a key regulator of human airway smooth muscle cell viability PMID: 22160308
    4. Results suggest that all peptide substrates adopt a common binding mode in the protein farnesyltransferase and geranylgeranyltransferase active site. PMID: 15451670
    5. Geranylgeranyltransferase inhibitor-2147 (GGTI-2147), an inhibitor of protein prenylation, elicited significant inhibition of glucose-stimulated insulin secretion from INS 832/13 islet cells. PMID: 17192483
    6. FTase, via its tubulin-association, is a critical upstream regulator of HDAC6 activity PMID: 19228685

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  • 蛋白家族：
    Protein prenyltransferase subunit alpha family
  • 数据库链接：

    HGNC: 3782

    OMIM: 134635

    KEGG: hsa:2339

    STRING: 9606.ENSP00000303423

    UniGene: Hs.370312