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FOXD1 Antibody

  • 货号：
    CSB-PA291867
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA291867(FOXD1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q16676
  • 基因名：
    FOXD1
  • 别名：
    Brain Factor 2 antibody; FKH L8 antibody; FKHL 8 antibody; FKHL8 antibody; Forkhead (Drosophila) like 8 antibody; Forkhead box D1 antibody; Forkhead box protein D1 antibody; Forkhead drosophila homolog like 8 antibody; Forkhead like 8 antibody; Forkhead related activator 4 antibody; Forkhead related protein FKHL8 antibody; Forkhead related transcription factor 4 antibody; Forkhead-related protein FKHL8 antibody; Forkhead-related transcription factor 4 antibody; FOX D1 antibody; FOXD 1 antibody; foxd1 antibody; FOXD1_HUMAN antibody; FREAC 4 antibody; FREAC-4 antibody; FREAC4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human FOXD1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:500-1:5000
    IHC 1:10-1:50
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor involved in regulation of gene expression in a variety of processes, including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells. Involved in transcriptional activation of PGF and C3 genes.
  • 基因功能参考文献：
    1. as well as stemness abilities but stronger senescence and higher apoptosis rate. CONCLUSION: We found that overexpression of miR-338-5p suppresses glioma cell proliferation, migration, and invasion and accelerates its senescence and apoptosis by decreasing FOXD1 expression via inhibition of activation of MAPK-signaling pathway. PMID: 30225541
    2. FOXD1 is overexpressed in osteosarcoma while MiR-30a-5p is lowexpressed. MiR-30a-5p directly regulates FOXD1 by binding its 3'-UTR. PMID: 29936179
    3. FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation PMID: 30158529
    4. FOXD1 promoted the expression of Plk2 mRNA and protein in colorectal cancer cells. PMID: 29864920
    5. Results showed that FOXD1 is a major actor in mammalian reproduction as sequence variants generated recurrent spontaneous abortion (RSA) and embryonic resorption (ER). Data propose that the FOXD1-p.429AlaAla mutation might be used as an RSA molecular marker while FOXD1 p.Ala88Gly variant might have a protective effect. PMID: 27805902
    6. our findings define a FOXD1-ALDH1A3 pathway in controling the clonogenic and tumorigenic potential of mesenchymal glioma stem-like cells in glioblastoma tumors PMID: 27569208
    7. The role of FOXD1 in glioma tumorigenesis, migration and progression.High FOXD1 expression in glioma. PMID: 28075458
    8. FOXD1 promotes breast cancer proliferation and chemotherapeutic drug resistance by targeting p27 PMID: 25462566
    9. Lung cancer patients with high FOXD1 expression survive for a significantly shorter time than those with low FOXD1 expression. PMID: 25550559
    10. In this review, we focus on the role of four specific FOX factors (FOXD1, FOXL2, FOXO1 and FOXP3) in gonadotropin hormone production PMID: 24099863
    11. the level of Smad6s can alter the level of TGF-beta and the subsequent induction of PAI-1 via a FoxD1 transcription site PMID: 15716278

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 3802

    OMIM: 601091

    KEGG: hsa:2297

    STRING: 9606.ENSP00000462795

    UniGene: Hs.519385