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FOXL1 Antibody

  • 货号：
    CSB-PA827930
  • 规格：
    ￥1100
  • 图片：
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: CSB-PA827930(FOXL1 Antibody) at dilution 1/850, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q12952
  • 基因名：
    FOXL1
  • 别名：
    FKH 6 antibody; FKH6 antibody; FKHL 11 antibody; FKHL11 antibody; Forkhead (Drosophila) like 11 antibody; Forkhead box L1 antibody; Forkhead box protein L1 antibody; Forkhead related protein FKHL11 antibody; Forkhead related transcription factor 7 antibody; Forkhead-related protein FKHL11 antibody; Forkhead-related transcription factor 7 antibody; FOX L1 antibody; FOXL 1 antibody; Foxl1 antibody; FOXL1_HUMAN antibody; FREAC 7 antibody; FREAC-7 antibody; FREAC7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human FOXL1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors.
  • 基因功能参考文献：
    1. FOXL1 inhibited the proliferation, invasion, and migration of breast cancer.FOXL1 expression was reduced in breast cancer. PMID: 27938507
    2. our findings provide evidence that FOXL1 might serve as a candidate tumor suppressor and a potential prognostic biomarker for gastric cancer PMID: 26960689
    3. the downregulation of FOXL1 expression was associated with osteosarcoma cell growth. Restoration of FOXL1 gene expression by gene therapy may have a therapeutic potential for patients with osteosarcoma PMID: 26062977
    4. dysregulated FOXL1 is involved in tumorigenesis and progression of gallbladder cancer. PMID: 25010679
    5. results suggest that Foxl1 plays an inhibitory role in renal tumor progression. PMID: 24427331
    6. Lower FOXL1 expression is correlated with metastasis and advanced pathologic stage of pancreatic cancer. PMID: 23801748
    7. two novel de novo mutations in rare patients inherited gene variants in FOXL1. PMID: 21457232
    8. FUS-CREB3L2/L1-positive sarcomas show a specific gene expression profile with upregulation of CD24 and FOXL1. PMID: 21536545

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 3817

    OMIM: 603252

    KEGG: hsa:2300

    STRING: 9606.ENSP00000326272

    UniGene: Hs.533830