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FOXN1 Antibody

  • 货号：
    CSB-PA966011
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA966011(FOXN1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    O15353
  • 基因名：
    FOXN1
  • 别名：
    FKHL20 antibody; Forkhead box N1 antibody; Forkhead box protein N1 antibody; FOXN 1 antibody; FOXN1 antibody; FOXN1_HUMAN antibody; RONU antibody; Rowett nude antibody; Transcription factor winged-helix nude antibody; WHN antibody; Winged helix nude antibody; Winged-helix transcription factor nude antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human FOXN1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C. Plays a crucial role in the early prenatal stages of T-cell ontogeny.
  • 基因功能参考文献：
    1. FOXN1 founder Italian mutation identified in an indian newborn with severe combined immunodeficiency. PMID: 28636882
    2. Whole-exome sequencing in a South American cohort links ALDH1A3, FOXN1 and RARB/retinoic acid regulation pathways to autism spectrum disorders. PMID: 26352270
    3. Identification of a unique mutation in FOXN1 that led to severe combined immunodeficiency in a female infant is reported. PMID: 25173801
    4. These results show that miR-18b and miR-518b are upstream controllers of FOXN1-directed epithelial lineage development. PMID: 24383669
    5. The retinoid-related orphan receptor RORalpha promotes keratinocyte differentiation via FOXN1. PMID: 23922987
    6. This is the first description of leucoderma occurring in a patient with Foxn1 deficiency, as well as the first report of this pigment abnormality following thymus transplantation. PMID: 22721479
    7. results show that FOXN1 is crucial for in utero T cell development, but not for B and NK cell differentiation PMID: 21507891
    8. role of FOXN1 in immunological disorders characterized by abnormal T-cell development or abnormal T-cell regulatory homeostasis [Review] PMID: 20429426
    9. study uncovered a positive regulatory loop between FGFR3 and FOXN1 that underlies a benign versus malignant skin tumor phenotype PMID: 19729838
    10. Mutation of the FOXN1 gene is associated with congenital severe combined immunodeficiency associated with alopecia PMID: 15180707
    11. These results establish a role for FOXN1 in initiation of terminal differentiation and implicate Akt in subsequent events. PMID: 15316080
    12. Mechanisms and signaling pathways by which Foxn1 modulates keratinocyte differentiation in hair follicle and nail apparatus. Molecular and functional consequences of loss of function of Foxn1 protein in skin. Review. PMID: 16232301
    13. Foxn1 is a sensitive and specific marker for thymoma and thymic carcinoma. PMID: 17592270
    14. Foxn1/FGF2 pathway involved in instructing melanocytes where to place pigment. PMID: 17803914

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  • 相关疾病：
    T-cell immunodeficiency, congenital alopecia, and nail dystrophy (TIDAND)
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in thymus.
  • 数据库链接：

    HGNC: 12765

    OMIM: 600838

    KEGG: hsa:8456

    STRING: 9606.ENSP00000226247

    UniGene: Hs.58611