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FTCD Antibody

  • 货号：
    CSB-PA009029ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: FTCD antibody at 5.46μg/ml
      Lane 1: HepG2 whole cell lysate
      Lane 2: 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 59, 62, 53, 17 kDa
      Observed band size: 59 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA009029ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA009029ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FTCD Polyclonal antibody
  • Uniprot No.：
    O95954
  • 基因名：
    FTCD
  • 别名：
    Formimidoyltetrahydrofolate cyclodeaminase antibody; Formimidoyltransferase cyclodeaminase antibody; Formiminotetrahydrofolate cyclodeaminase antibody; Formiminotransferase cyclodeaminase antibody; Formiminotransferase-cyclodeaminase antibody; FTCD antibody; FTCD_HUMAN antibody; Glutamate formiminotransferase antibody; Glutamate formyltransferase antibody; LCHC 1 antibody; LCHC1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Formimidoyltransferase-cyclodeaminase protein (412-541AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.; Binds and promotes bundling of vimentin filaments originating from the Golgi.
  • 基因功能参考文献：
    1. The formiminotransferase-cyclodeaminase allelic spectrum comprised of 12 distinct variants including 5 missense alterations, an in-frame deletion, two frameshift variants and four nonsense variants with the remaining alterations predicted to affect mRNA processing/stability. PMID: 29178637
    2. FTCD is a positive regulator of the hypoxia-HIF signaling pathway and has an important role in cell proliferation, metabolism and migration in HepG2 cells PMID: 24686083
    3. The FTCD promoter is activated by serum depletion according to promoter reporter assays in HEK 293 cells. PMID: 20494980
    4. Scyl1 interacts with 58K/formiminotransferase cyclodeaminase (FTCD) and golgin p115, and is required for the maintenance of Golgi morphology PMID: 20209057
    5. Disease-causing mutations have been identified in the FTCD gene in three patients with the putative autosomal recessive disorder glutamate formiminotransferase deficiency. PMID: 12815595

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  • 相关疾病：
    Glutamate formiminotransferase deficiency (FIGLU-URIA)
  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus. Note=More abundantly located around the mother centriole.
  • 蛋白家族：
    Cyclodeaminase/cyclohydrolase family; Formiminotransferase family
  • 数据库链接：

    HGNC: 3974

    OMIM: 229100

    KEGG: hsa:10841

    STRING: 9606.ENSP00000291670

    UniGene: Hs.415846