Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. FYCO1 Antibody

FYCO1 Antibody

  • 货号：
    CSB-PA796500
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from JurKat cells, using FYCO1 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FYCO1 Polyclonal antibody
  • Uniprot No.：
    Q9BQS8
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from Internal of Human FYCO1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May mediate microtubule plus end-directed vesicle transport.
  • 基因功能参考文献：
    1. FYCO1 regulates accumulation of post-mitotic midbodies by mediating LC3-dependent midbody degradation PMID: 29196475
    2. FYCO1 and MAP1LC3A interact through a novel binding mode that involves Atg8-family proteins PMID: 27246247
    3. Rare missense variants in FYCO1 are overrepresented in sporadic inclusion body myositis patients. PMID: 28009083
    4. FYCO1 requires a functional LC3A/B-preferring LC3-interacting Region (LIR) motif to facilitate efficient maturation of autophagosomes under basal conditions, whereas starvation-induced autophagy was unaffected PMID: 26468287
    5. FYCO1 is involved in lens development and transparency in humans, and mutations in this gene are one of the most common causes of autosomal-recessive congenital cataracts in the Pakistani population. PMID: 21636066
    6. We have characterized the LC3-, Rab7-, and phosphatidylinositol-3-phosphate-binding domains in FYCO1 and mapped part of the CC region essential for MT plus end-directed transport. PMID: 20100911
    7. Maps to a region of chromosome 3p21.3 which is frequently deleted in tumors. PMID: 11896456

    显示更多

    收起更多

  • 相关疾病：
    Cataract 18 (CTRCT18)
  • 亚细胞定位：
    Cytoplasmic vesicle, autophagosome. Endosome. Lysosome. Note=Localizes to the external but not to the internal membrane of autophagosomes, and upon autophagosome/late endosome/lysosome fusion, it stays on the external surface of autolysosomes.
  • 组织特异性：
    Expressed in heart and skeletal muscle.
  • 数据库链接：

    HGNC: 14673

    OMIM: 607182

    KEGG: hsa:79443

    STRING: 9606.ENSP00000296137

    UniGene: Hs.200227