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G6PC2 Antibody

  • 货号：
    CSB-PA873624LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA873624LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA873624LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品描述：

    The immunization of rabbits with the recombinant human G6PC2 protein (78-115AA) and final purification from rabbit antiserum by protein G causes the creation of the anti-G6PC2 antibody. This G6PC2 antibody is a polyclonal antibody and occurs as an unconjugated IgG. Its purity is 95%+. It is only reactive with human G6PC2 protein, which is present in pancreatic islets and exhibits no phosphohydrolase activity but is a major target of cell-mediated autoimmunity in diabetes. And this anti-G6PC2 antibody can be used to detect the G6PC2 protein in ELISA, IHC, and IF applications.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) G6PC2 Polyclonal antibody
  • Uniprot No.：
    Q9NQR9
  • 基因名：
  • 别名：
    G6PC2 antibody; IGRPGlucose-6-phosphatase 2 antibody; G-6-Pase 2 antibody; G6Pase 2 antibody; EC 3.1.3.9 antibody; Islet-specific glucose-6-phosphatase catalytic subunit-related protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Glucose-6-phosphatase 2 protein (78-115AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，G6PC2 Antibody (CSB-PA873624LA01HU)，的标记方式是Non-conjugated。对于G6PC2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA873624LB01HU G6PC2 Antibody, HRP conjugated ELISA
    FITC CSB-PA873624LC01HU G6PC2 Antibody, FITC conjugated
    Biotin CSB-PA873624LD01HU G6PC2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis.
  • 基因功能参考文献：
    1. The results suggest that the GCKR and G6PC2 genes may contribute to the risk of type 2 diabetes independently and/or in an interactive manner in the Han Chinese population. PMID: 30055620
    2. The variant in TCF7L2 that increases fasting glucose levels increases between-subject variance, whereas variants in GCK and G6PC2 that increase fasting glucose levels decrease between-subject variance. PMID: 28783164
    3. All three allele variants of G6PC2 (rs560887, rs16856187 and rs573225) are associated with elevated fasting glucose, with two variants (rs560887 in the Caucasians subgroup and rs16856187 under the allele and dominant model) being associated with T2 diabetes as well.[meta-analysis] PMID: 28704540
    4. these studies identify multiple G6PC2 variants that have the potential to be associated with altered FBG in humans. PMID: 27611587
    5. Data suggest that islet-specific glucose 6 phosphatase catalytic subunit-related protein (IGRP)-specific CD4(+) helper T (Th) cells play a unique pathogenic role in adult-onset T1D (AT1D). PMID: 26341315
    6. rs560887 associated with increased fasting glucose levels PMID: 25078492
    7. we identified coding variants at several GWAS loci which point to the genes underlying these association signals. Importantly, we found that multiple coding variants in G6PC2 result in a loss of protein function and lower fasting glucose levels. PMID: 25625282
    8. three novel G6PC2 variants were discovered that occur in islets only, leading to protein truncations, frame shifts and neo-sequences prone to immunogenicity. PMID: 24030068
    9. GCKR rs780094 variant confers high cross-ethnicity risk for the development of T2DM, while significant associations between GCK, MTNR1B and G6PC2 variants and T2DM risk are limited to Caucasians. PMID: 23840762
    10. polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels PMID: 23508304
    11. A single nucleotide polymorphism in the beta cell gene G6PC2 may correlate with preserved insulin secretion in type 1 diabetes. PMID: 22438186
    12. one of the newly identified spontaneously reactive epitopes (P8 [IGRP(55-72)]) is highly conserved between mice and man, suggesting that it might also be a target of HLA-DQ8-restricted T cells in diabetic human subjects PMID: 22983906
    13. Variation at the rs560887 locus of G6PC2 is associated with worse glycated haemoglobin levels in individuals with GCK mutations; GG homozygotes are more likely to meet diagnostic criteria for diabetes based on HbA(1c) level. PMID: 22486180
    14. Children and adolescents carrying glucose-raising alleles of G6PC2, MTNR1B, GCK, and GLIS3 also showed reduced beta-cell function, as indicated by homeostasis model assessment of beta-cell function. PMID: 21515849
    15. The effects of hyperglycemia on insulin secretion override the more subtle effects of genetic variation in the G6PC2 locus on insulin secretion. PMID: 20826583
    16. Common variants of MTNR1B, G6PC2 and GCK are associated with elevated FPG and impaired insulin secretion, both individually and jointly, suggesting that these risk alleles may precipitate or perpetuate hyperglycemia in predisposed individuals. PMID: 20628598
    17. Study showed that SNPs from GCK, G6PC2 and MTNR1B modulated the fasting glucose levels in the normoglycaemic population while SNPs from G6PC2 and GCKR was associated with type 2 diabetes. PMID: 20668700
    18. Potential role linking single nucleotide polymphism in G6PC2 to variations in fasting blood glucose. PMID: 20622168
    19. Fasting glucose association at G6PC2 is replicable across ethnic groups, although ethnic diversity in the pattern and strength of linkage disequilibrium exists. PMID: 19937311
    20. results independently confirm the robust association of glucose-6-phosphatase catalytic 2(G6PC2)/rs560887 with fasting plasma glucose levels in non-diabetic non-Hispanic white Americans PMID: 20029179
    21. IGRP is likely the authentic islet-specific glucose-6-phosphatase catalytic subunit, and selective inhibitors to this molecule can be obtained PMID: 14722102
    22. Data show that islet-specific glucose-6-phosphatase-related protein is an endoplasmic reticulum membrane glycoprotein, and is degraded through the proteasome pathway that generates the major histocompatibility complex class I-presented peptides. PMID: 15044018
    23. Alpha mutants containing the beta cell antigen sequence are preferentially degraded in cells, which prevents targeting by pathogenic CD8+ T cells implying that IGRP levels in beta cells could dictate susceptibilities to diabetes. PMID: 16012821
    24. This study demonstrates the prevalence of CD4+ IGRP-specific T cells not only in subjects with type I diabetes, but also in healthy individuals carrying the DR0301 or DR0401 haplotypes. PMID: 16493034
    25. Differential tissue expression may aid in designing synthetic peptides for the identification of IGRP-specific autoreactive T cells in patients with type 1 diabetes. PMID: 16520917
    26. human CD8 T cell clone against this epitope, which confirms that this IGRP epitope is shared across species. PMID: 17376840
    27. missense mutation in exon 4, L173P, found in glycogen storage disease type Ia PMID: 17607665
    28. SNP rs560887 was associated with fasting plasma glucose (FPG); it is speculated that G6PC2 regulates FPG by modulating the set point for glucose-stimulated insulin secretion in pancreatic beta cells PMID: 18451265
    29. Genetic Polymorphisms of the G6PC2 gene may underlie variation in fasting blood glucose levels, and genetic Polymorphisms of the ABCB11 gene may also contribute to such variation. PMID: 18521185
    30. Data suggest that a group of transcription factors, including MafA and Foxa2, regulate expression of two major autoantigens in type 1 diabetes, including islet-specific glucose-6-phosphatase catalytic subunit-related protein. PMID: 18753309
    31. rs573225 is a functional cis-regulatory (epi)-single-nucleotide polymorphism (SNP) of G6PC2 associated with glucose-insulin homeostasis in obese children, likely to explain the results of recent genome-wide association studies in nondiabetic adults. PMID: 18984742
    32. Mutations and single nucleotide polymorphisms in this protein do not conribute to neonatal or early infant type 1 diabetes. PMID: 19238352
    33. Variations and single-nucleotide polymorphisms are associated in variations in fasting plasma glucose and an increased risk of type 2 diabetes. PMID: 19533084
    34. The common rs560887 G allele in the G6PC2/ABCB11 locus is associated with increased fasting glycaemia and increased risk of IFG, associations that may be partly related to an increased basal hepatic glucose production rate. PMID: 19669124
    35. Data suggest that variation in GCK and G6PC2 have additive effects on both fasting glucose and insulin secretion. PMID: 19741163
    36. SNP rs16856187 was associated with type 2 diabetes and fasting plasma glucose in the Chinese population; carriers of the A allele displayed a higher risk for type 2 diabetes and a lower fasting plasma glucose level in the controls. PMID: 19082990

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Glucose-6-phosphatase family
  • 组织特异性：
    Specifically expressed in pancreas and also detected to a lower extent in testis. Expressed by most islet cells in the pancreas (at protein level).
  • 数据库链接：

    HGNC: 28906

    OMIM: 608058

    KEGG: hsa:57818

    STRING: 9606.ENSP00000364512

    UniGene: Hs.283963