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GABPB1 Antibody

  • 货号：
    CSB-PA009138GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q06547
  • 基因名：
    GABPB1
  • 别名：
    BABPB2 antibody; E4TF1 antibody; E4TF1-47 antibody; E4TF1-53 antibody; E4TF1B antibody; GA binding protein transcription factor beta subunit 1 transcript variant gamma 2 antibody; GA binding protein transcription factor, beta subunit 1 antibody; GA binding protein transcription factor, beta subunit 2 antibody; GA-binding protein subunit beta-1 antibody; GABP subunit beta-1 antibody; GABP subunit beta-2 antibody; GABP1_HUMAN antibody; GABPB antibody; GABPB-1 antibody; GABPB-2 antibody; GABPB1 antibody; GABPB2 antibody; NRF2B1 antibody; NRF2B2 antibody; Nuclear respiratory factor 2 antibody; Transcription factor E4TF1-47 antibody; Transcription factor E4TF1-53 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human GABPB1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor capable of interacting with purine rich repeats (GA repeats). Acts as a a master regulator of nuclear-encoded mitochondrial genes.; (Microbial infection) Necessary for the expression of the Adenovirus E4 gene.
  • 基因功能参考文献：
    1. Data revealed high expression of GABPB1 in clear cell renal cell carcinoma (ccRCC) tissues and cell lines. Its knockdown significantly decreased the colony formation ability via induction of p21Waf/Cip1 expression. Furthermore, the patients at high risk of a poor survival outcome exhibited the highest expression level of GABPB1. These findings imply that GABPB1 serves an important role in the progression of ccRCC. PMID: 29845229
    2. Ectopic overexpression of a dominant-negative acting GABP mutant led to impaired myeloid differentiation of CD34(+) hematopoietic stem/progenitor cells. PMID: 27100840
    3. role for GABPA/B1 as the critical ETS transcription factors deregulating SDHD expression in the context of highly recurrent promoter mutations in melanoma. PMID: 28108517
    4. GABP beta is required for YAP expression in vitro and in vivo, and that YAP is an important effector downstream of GABP for cell survival and cell-cycle progression. PMID: 23684612
    5. The NRF-2beta nuclear localization signal (NLS) is an unusual but is, nevertheless, a bona fide monopartite-type NLS. PMID: 23856623
    6. NRF-1 and GABP expression is coordinated by NRF-1's activation of the GABPbeta promoter PMID: 21609478
    7. Data show that BRAF knockdown led to suppression of the expression of the GABPbeta, which involved in regulating HPR1 promoter activity. PMID: 21076620
    8. Mutation of a nuclear respiratory factor 2 binding site in the 5' untranslated region of the ADSL gene in three patients with adenylosuccinate lyase deficiency. PMID: 12016589
    9. Results point out that brain-specific angiogenesis inhibitor 2 controls VEGF transcription through GA-binding protein under normal conditions and cerebral ischemia [GA-binding protein gamma]. PMID: 16412436
    10. serum-responsive GABP binding to Ets-binding sites activates the KIS promoter, leading to KIS gene expression, cell migration, and cell cycle progression PMID: 17726090
    11. The results are consistent with a pathway whereby PRC regulates NRF-2-dependent genes through a multiprotein complex involving HCF-1.[NRF-2beta] PMID: 18343819
    12. The cyrstal structure of a ternary complex containing the mouse GA binding protein transcription factor, beta subunit 2, was resolved at 2.15 angstrom resolution. PMID: 9461436

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 4074

    OMIM: 600610

    KEGG: hsa:2553

    STRING: 9606.ENSP00000220429

    UniGene: Hs.654350