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GABRA6 Antibody

  • 货号：
    CSB-PA002619
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of MOUSE-BRAIN cells using GABAA Rα6 Polyclonal Antibody
    • Western Blot analysis of MOUSE-BRAIN cells using GABAA Rα6 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q16445
  • 基因名：
  • 别名：
    GABA A antibody; GABA A Receptor alpha 6 polypeptide antibody; GABA A receptor alpha 6 antibody; GABA A receptor subunit alpha 6 antibody; GABA subunit A receptor alpha 6 antibody; GABA(A) receptor subunit alpha-6 antibody; GABRA 6 antibody; GABRA6 antibody; Gamma aminobutyric acid A receptor alpha 6 antibody; Gamma aminobutyric acid GABA A receptor alpha 6 antibody; Gamma aminobutyric acid receptor subunit alpha 6 antibody; Gamma-aminobutyric acid receptor subunit alpha-6 antibody; GBRA6_HUMAN antibody; MGC116903 antibody; MGC116904 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human GABAA Rα6.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
  • 基因功能参考文献：
    1. TMEM132D, COMT and GABRA6 gene polymorphisms may influence susceptibility to panic disorder(PD) and major depressive disorder(MDD)in Japanese adults; these variants may increase vulnerability to PD by modulating oligodendrocytes and GABA and dopaminergic functions in related brain regions, altering neuronal processing of anxiety-related emotional signals PMID: 25974322
    2. NOS3, GABRA6, child abuse, neighborhood crime Gene x Gene, Environment x Environment, and Gene x Environment interactions are associated with different patterns of respiratory sinus arrhythmia reactivity. PMID: 26535938
    3. The gene-gene interaction at two loci involving GABRA6 and Synapsin II revealed a significant association for development of idiopathic generalized epilepsy. PMID: 25088614
    4. genetic association study in Chinese Han population: Data suggest an SNP in GABRA6 (rs3219151) is associated with decreased predisposition to schizophrenia via alteration of miroRNA binding to target in 3-prime-untranslated region of GABRA6 mRNA. PMID: 23332465
    5. GABRA6 mutation, R46W, was identified as a susceptibility gene that may contribute to the pathogenesis of childhood absence epilepsy and cause neuronal disinhibition and increase in seizures via a reduction of alphabetagamma and alphabetadelta receptor function and expression PMID: 21930603
    6. Part of the interindividual differences observed for anxiety traits measured by the Harm Avoidance dimension could be explained by the GABRA6 gene variability. PMID: 21902679
    7. significant involvement of alpha (GABRA6) and beta (GABRB2) subunits of GABA(A) receptor in epilepsy susceptibility in north Indian population PMID: 21420396
    8. studies have found prefrontal cortical GABA(A) receptor alpha subunit alterations in schizophrenia PMID: 20100621
    9. These findings support a role for the serotonin transporter and GABA(A) alpha6 subunit in depression-related traits. PMID: 14744464
    10. The T1521C polymorphism in the GABRA6 gene is associated with specific personality characteristics as well as a marked attenuation in hormonal and blood pressure responses to psychological stress. PMID: 15197399
    11. GABRA6 expression is regulated by NFI in cerebellar granule neurons PMID: 15466411
    12. Findings support a role for GABRA6 (Pro385Ser) in perceived parenting. PMID: 16402352
    13. Polymorphism not associated with panic disorder. PMID: 17167337
    14. Chinese patients with certain psychiatric characteristics and GABRA6 heterozygosity are probably predisposed to functional heartburn PMID: 17295876
    15. The T allele of the 1519T>C GABA(A)alpha6 gene may be one of the modulating factors associated with changes in craving for alcohol and food during treatment of patients with alcohol dependence. PMID: 18616664
    16. Significant matching effects were found for polymorphisms at the DRD2, GABRA6 and GABRB2 gene. In addition, a trend was found for the OPRM1 polymorphism. PMID: 19523047

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  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRA6 sub-subfamily
  • 数据库链接：

    HGNC: 4080

    OMIM: 137143

    KEGG: hsa:2559

    STRING: 9606.ENSP00000274545

    UniGene: Hs.90791