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GADD45GIP1 Antibody

  • 货号：
    CSB-PA070212
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q8TAE8
  • 基因名：
    GADD45GIP1
  • 别名：
    39S ribosomal protein L59 mitochondrial antibody; CKBBP2 antibody; CKbetaBP2 antibody; CKII beta associating protein antibody; CKII beta binding protein 2 antibody; CKII beta-associating protein antibody; CR6 interacting factor 1 antibody; CR6-interacting factor 1 antibody; CRIF1 antibody; G45IP_HUMAN antibody; GADD45G interacting protein 1 antibody; Gadd45gip1 antibody; Growth arrest and DNA damage inducible GADD45G interacting protein antibody; growth arrest and DNA damage inducible, gamma interacting protein 1 antibody; Growth arrest and DNA damage-inducible proteins-interacting protein 1 antibody; MGC4667 antibody; MGC4758 antibody; MRP L59 antibody; p53 responsive gene 6 antibody; p53 responsive gene 6 protein antibody; p53-responsive gene 6 protein antibody; Papillomavirus L2 interacting nuclear protein 1 antibody; Papillomavirus L2-interacting nuclear protein 1 antibody; PLINP 1 antibody; PLINP antibody; PLINP-1 antibody; PLINP1 antibody; PRG6 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CRIF1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
  • 基因功能参考文献：
    1. NRF2 Ser40 phosphorylation was inhibited in Crif1-deficient bone marrow multipotent mesenchymal stromal cells even in the presence of three kinds of PKC agonists, suggesting that CRIF1 might co-activate PKC-delta to phosphorylate NRF2 Ser40. PMID: 28819452
    2. strongly suggest that CRIF1 deficiency promotes endothelial cell inflammation by increasing VCAM-1 expression, elevating inflammatory cytokines levels, and activating the transcription factor NF-kappaB, all of which were inhibited by SIRT1 overexpression PMID: 29474366
    3. Results demonstrate that knockdown of CRIF1 in HUVECs induces mitochondrial dysfunction and reduces SIRT1 expression along with decreased eNOS phosphorylation and increased eNOS acetylation, thereby promoting endothelial dysfunction. These findings indicate that CRIF1 plays an important role in maintaining mitochondrial and endothelial function through its effects on the SIRT1-eNOS pathway. PMID: 28117598
    4. SNF5 is indispensable for CRIF1-enhanced p53 activity and its function in the suppression of cell cycle arrest in human cancer cells. PMID: 28235567
    5. Study shows that Lck interacts with CRIF1 in the mitochondria and negatively regulates CRIF1-mediated translation of mitochondrion-encoded proteins. PMID: 26210498
    6. our results support a novel function of nuclear Lck in promoting human leukemic T cell survival through interaction with a tumor suppressor, CRIF1 PMID: 25997448
    7. Crif1 is an indispensable regulator of PKAalpha cat that modulates the PKA/CREB signaling pathway to promote adipogenic differentiation of bone marrow mesenchymal stem cells after irradiation PMID: 25847389
    8. The results identify the ROS-Sp1-Crif1 pathway to be a new mechanism underlying Abeta-induced mitochondrial dysfunction and suggest that ROS-mediated downregulation of Crif1 is a crucial event in AD pathology. PMID: 25361083
    9. CRIF1 knockdown partially induces endothelial activation via increased ROS production and phosphorylation of p66shc PMID: 24906005
    10. CRIF1 may play a regulatory role in the BM microenvironment-induced leukemia cell cycle arrest possibly through interacting with CDK2 and acting as a cyclin-dependent kinase inhibitor. PMID: 24520316
    11. CKbetaBP2/CRIF1 is expressed with STAT3 in prostate cancer where STAT3 may help to offset the AR repressor effect of CKbetaBP2/CRIF1. PMID: 24103312
    12. results indicated cell cycle arrest of Jurkat cells in the G0/G1 phase to be induced by primary cultured leukemic BMSCs associated with increased expression of CRIF1 by leukemic cells PMID: 21911160
    13. CRIF1, unlike KEAP1 (which only interacts with N-terminal region of NRF2), physically interacts with both N- and C-terminal regions of NRF2 and promotes NRF2 ubiquitination and subsequent proteasome-mediated NRF2 protein degradation PMID: 20427290
    14. results suggest that CRIF1 is a novel nuclear protein that interacts with Gadd45 and may play a role in negative regulation of cell cycle progression and cell growth PMID: 12716909
    15. Phosphorylation of serine-221 in CKBBP2/CRIF1 promotes proliferation of green monkey COS7 cells. PMID: 17069992
    16. NAC-1 contributes to tumor growth and survival by at least inhibiting Gadd45GIP1 expression, which has a tumor suppressor effect in cancer cells. PMID: 17804717
    17. Results suggest that CRIF1 acts as an AR corepressor and may play an important role in the regulation of AR-positive growth of prostate cancer. PMID: 17885209

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  • 亚细胞定位：
    Mitochondrion. Nucleus.
  • 蛋白家族：
    Mitochondrion-specific ribosomal protein mL64 family
  • 组织特异性：
    Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary th
  • 数据库链接：

    HGNC: 29996

    OMIM: 605162

    KEGG: hsa:90480

    STRING: 9606.ENSP00000323065

    UniGene: Hs.515164