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GAS2 Antibody

  • 货号：
    CSB-PA290331
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA290331(GAS2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    O43903
  • 基因名：
    GAS2
  • 别名：
    GAS 2 antibody; GAS-2 antibody; Gas2 antibody; GAS2_HUMAN antibody; Growth arrest specific 2 antibody; Growth arrest specific protein 2 antibody; Growth arrest-specific protein 2 antibody; MGC32610 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human GAS2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process.
  • 基因功能参考文献：
    1. Taken together, our results demonstrated the deregulation of GAS2 in both AML and ALL and the requirement of GAS2-Calpain2 axis for the growth of leukemic cells. PMID: 26358320
    2. Truncated HBx deregulates cell growth via direct silencing of GAS2 and thereby provides a survival advantage for pre-neoplastic hepatocytes to facilitate cancer development via TP53 signaling. PMID: 25925944
    3. GAS2 is up-regulated in chronic myeloid leukemia cells. PMID: 24465953
    4. Studies have identified a Gas2/calpain-dependent mechanism by which ICSBP influences beta-catenin activity in myeloid leukemia. PMID: 20679491
    5. Gas2DN can increase the activity of calpain and induce degradation of stabilized/mutated beta-catenin PMID: 15817486

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton, stress fiber. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    GAS2 family
  • 组织特异性：
    Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen.
  • 数据库链接：

    HGNC: 4167

    OMIM: 602835

    KEGG: hsa:2620

    STRING: 9606.ENSP00000278187

    UniGene: Hs.711297