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GATA6 Antibody

  • 货号：
    CSB-PA478144
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA478144(GATA6 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q92908
  • 基因名：
    GATA6
  • 别名：
    Gata binding factor 6 antibody; Gata binding protein 6 antibody; GATA-binding factor 6 antibody; Gata6 antibody; GATA6_HUMAN antibody; Transcription factor Gata 6 antibody; Transcription factor GATA-6 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human GATA6
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:10000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional activator. Regulates SEMA3C and PLXNA2. Involved in gene regulation specifically in the gastric epithelium. May regulate genes that protect epithelial cells from bacterial infection. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. In human skin, controls several physiological processes contributing to homeostasis of the upper pilosebaceous unit. Triggers ductal and sebaceous differentiation as well as limits cell proliferation and lipid production to prevent hyperseborrhoea. Mediates the effects of retinoic acid on sebocyte proliferation, differentiation and lipid production. Also contributes to immune regulation of sebocytes and antimicrobial responses by modulating the expression of anti-inflammatory genes such as IL10 and pro-inflammatory genes such as IL6, TLR2, TLR4, and IFNG. Activates TGFB1 signaling which controls the interfollicular epidermis fate.
  • 基因功能参考文献：
    1. The long non-coding antisense transcript of GATA6 (GATA6-AS) interacts with the epigenetic regulator LOXL2 to regulate endothelial gene expression via changes in histone methylation. A number of angiogenesis- and hypoxia-related genes were downregulated by GATA6-AS silencing. PMID: 29339785
    2. High GATA6 expression is associated with Gastric Cancer. PMID: 29321084
    3. Increased GATA6 expression is associated with laryngeal squamous cell carcinoma. PMID: 29517349
    4. These findings suggest that GATA6 might interact with HNF4alpha and contribute to the development of mucinous-type lung adenocarcinomas PMID: 29469192
    5. Genetic variants in GATA6 gene had severe pancreatic atrophy but with abundant beta cells and severe amyloidosis similar to type 2 diabetes. PMID: 28938416
    6. Study firstly associates GATA6 loss-of-function mutation with increased susceptibility to familial congenital bicuspid aortic valve (BAV) in humans, which provides novel insight into the molecular pathogenesis underlying BAV. PMID: 29653232
    7. loss of one GATA6 allele affects the differentiation of pancreatic progenitors from the early PDX1+ stage to the more mature PDX1+NKX6.1+ stage, leading to impaired formation of glucose-responsive beta-like cells; in addition to this GATA6 haploinsufficiency, also identified dosage-sensitive requirements for GATA6 and GATA4 in the formation of both definitive endoderm and pancreatic progenitor cells PMID: 28196600
    8. Results show that GATA6 protein levels are reduced in tissue samples from colon cancer patients with miR-196b upregulation and that GATA6 is a direct target of miR-196b. PMID: 27902469
    9. Our data suggested that miR-124 decreases GATA6 expression by targeting its 3'-UTR, which in turn inhibits cholangiocarcinoma invasion and metastasis. PMID: 28270130
    10. Gain-of-function mutations in GATA6 in both a family with early-onset Atrial Fibrillation and Atrioventricular Septal Defects was found. PMID: 27756709
    11. analysis of the TNF-insulin signaling with GATA6 reveals specific patterns of gene expression in cells receiving multiple stimuli PMID: 27273097
    12. These data show that GATA6 plays a critical role in endoderm and pancreas specification and beta-like cell functionality in humans. PMID: 28196690
    13. GATA6 variant frequency in sporadic CTDs patients was higher than that in other congenital heart diseases. PMID: 29101065
    14. Knockdown of GATA6 completely eliminated the effect of TCF1, while forced expression of GATA6 induced hESC differentiation PMID: 28943339
    15. In human Pancreatic Ductal Adenocarcinoma cells, GATA6 inhibits de-differentiation and epithelial-mesenchymal transition both directly and indirectly, through mechanism that involves the regulation of transcription factors, including FOXA1/2.Loss of GATA6 in PDAC primary samples is associated with altered differentiation and shorter overall patient survival. PMID: 27325420
    16. GATA6 induces expression of genes essential for growth of colon cancer cells under adherent conditions (REG4) and genes required for their clonogenicity (LGR5), and miR-363-GATA6-REG4/LGR5 signaling cascade promotes tumorigenicity of colon cancer cells. PMID: 26387746
    17. In the pancreas, Gata6 acts as a tumour suppressor by enforcing acinar cell differentiation, by directly and indirectly repressing ectopic differentiation programmes, and by regulating crucial cancer-related gene expression pathways. PMID: 25596178
    18. Our results, for the first time, portray a pivotal role of GATA6 in regulating metastatic behaviors of breast cancer cells PMID: 26505174
    19. miR-181b was upregulated by hypoxia in retinoblastoma in an HIF-1a-independent manner. Additionally, miR-181b exerts its angiogenic function, at least in part, by inhibiting PDCD10 and GATA6. PMID: 25872572
    20. data indicated that GATA-6 and Akt2 are involved in the mTORC1-mediated regulation of VSMC proliferation and differentiation. PMID: 25969542
    21. results show how genetic mutations in GATA6 may lead to functional inactivity and pancreatic agenesis in humans PMID: 25706805
    22. GATA6 expression is progressively increased during Barrett's oesophagus development and its malignant transformation to esophageal adenocarcinoma. PMID: 25445407
    23. association of GATA6 loss-of-function mutations with enhanced susceptibility to familial dilated cardiomyopathy PMID: 25119427
    24. These results establish SHP as a novel antihypertrophic regulator that acts by interfering with GATA6 signaling. PMID: 25015078
    25. SNPs within the GATA6 gene promoter identified in ventricular septal defects patients may change GATA6 levels, contributing to the VSD development as a risk factor. PMID: 25036032
    26. Three heterozygous missense mutationsof GATA-binding factor 6, c.151G>A (E51K), c.551G>A (S184N) and c.733G>C (G245R), were identified in patients with tetralogy of Fallot or persistent truncus arteriosus. PMID: 24841381
    27. analysis of the GATA6 transcriptional regulation in gastric cancer PMID: 24317510
    28. The results show that de novo mutations in GATA6 contribute to the development of congenital diaphragmatic hernia. PMID: 24385578
    29. Data suggest that levels of GATA6 in subcapsular zone of adrenal glands (zona glomerulosa) are not prominently different in subjects with primary aldosteronism, subjects with aldosterone-producing adrenocortical adenomas, or normal subjects. PMID: 24531914
    30. Based on the data presented in this paper, we conclude that the heterozygous nonsense mutation, p.Arg493X of GATA6 resulted in pancreatic agenesis and congenital heart defects. PMID: 24310933
    31. DNA sequence variants within the GATA6 gene promoter may contribute to the IIH development as a risk factor by changing the GATA6 levels PMID: 24949533
    32. GATA6 overexpression is associated with hepatic metastasis of colorectal cancer. PMID: 23784465
    33. FOG1, FOG2 and GATA-6 modulate the transcriptional up-regulation of HAMP in hepatocytes during inflammation. PMID: 24179092
    34. Spontaneously differentiated GATA6-expressed human embryonic stem cells represent an important cellular step in human embryonic development. PMID: 23746070
    35. Our 2 cases with novel GATA6 mutations add more phenotype characteristics of GATA6 haploinsufficiency PMID: 23635550
    36. Endothelial GATA-6 plays a critical role in the molecular mechanisms underlying endothelial cell dysfunction in pulmonary arterial hypertension. PMID: 23583651
    37. Novel mutations identified in the GATA6 gene are associated with tetralogy of Fallot. PMID: 23158662
    38. GATA6 and HOPX are critical nodes in a lineage-selective pathway that directly links effectors of airway epithelial specification to the inhibition of metastasis in the lung ADC subtype. PMID: 23707782
    39. Data suggest that GATA6 was an independent prognostic marker for overall survival and recurrence-free survival in cholangiocarcinoma (CCA). PMID: 23313142
    40. GATA6 mutation was identified in a patient with atrial fibrillation and co-segregated with the disease as an autosomal dominant trait in the family. PMID: 22750565
    41. Results imply that miRNA-145 indirectly targets BMP4 via GATA6 and is potentially involved in the development of Barrett Esophagus (BE). PMID: 22504665
    42. A novel heterozygous GATA6 mutation, p.G469V, was identified in a family with atrial fibrillation inherited in an autosomal dominant pattern. PMID: 22824924
    43. This is the first report on the association of somatic GATA6 loss-of-function mutation with increased susceptibility to Tetralogy of Fallot. PMID: 23175051
    44. mutation screening in 171 subjects with neonatal diabetes of unknown genetic etiology: Data suggest that GATA6 mutations account for a wide spectrum of neonatal diabetes; GATA6 mutations appear to be the major cause of pancreatic agenesis. PMID: 23223019
    45. The study characterized the CPI-17 promoter and identified binding sites for GATA-6 and nuclear factor kappa B (NF-kappaB). PMID: 23275439
    46. Dominantly inherited diabetes mellitus caused by GATA6 haploinsufficiency. PMID: 22962692
    47. GATA6 inactivating mutations are associated with heart defects and, inconsistently, with pancreatic agenesis and diabetes. PMID: 22806356
    48. Data indicate that two novel heterozygous GATA6 mutations, p.D404Y and p.E460X, were identified in two families with ventricular septal defect and tetralogy of Fallot, respectively. PMID: 23020118
    49. High methylation frequency of tested genes shows heterogeneity of glioblastoma epigenome and the importance of MGMT, GATA6 and CASP8 genes methylation in glioblastoma patient outcome. PMID: 22672670
    50. The entire coding region of the GATA6 gene, which encodes a zinc-finger transcription factor crucial to normal cardiogenesis, was sequenced in 130 unrelated patients with congenital ventricular septal defect. PMID: 22407241

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  • 相关疾病：
    Conotruncal heart malformations (CTHM); Atrial septal defect 9 (ASD9); Tetralogy of Fallot (TOF); Atrioventricular septal defect 5 (AVSD5); Pancreatic agenesis and congenital heart defects (PACHD)
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in heart, gut and gut-derived tissues. Expressed in skin upper pilosebaceous unit. Expression is decreased or lost in acne lesions.
  • 数据库链接：

    HGNC: 4174

    OMIM: 187500

    KEGG: hsa:2627

    STRING: 9606.ENSP00000269216

    UniGene: Hs.514746