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GBP2 Antibody

  • 货号：
    CSB-PA009298LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA009298LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA009298LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品描述：

    CUSABIO uses a peptide corresponding to amino acids 100-259 of the human GBP2 protein to immunize the rabbit to produce the anti-GBP2 antibody. This GBP2 polyclonal antibody exists as an unconjugated IgG isoform. It is reactive to human and mouse GBP2 protein. The GBP2 protein is an interferon-γ (IFN-γ)-induced GTPase that converts GTP to GDP and GMP. GBP2 also acts as a controlling factor for the proliferation and spreading of breast cancer cells. The high expression of GBP2 is related to a better prognosis of breast cancer. The purity of this antibody is over 95% using protein G purified. And it has been validated for use in ELISA, WB, IHC, and IF applications.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GBP2 Polyclonal antibody
  • Uniprot No.：
    P32456
  • 基因名：
  • 别名：
    GBP2Guanylate-binding protein 2 antibody; EC 3.6.5.- antibody; GTP-binding protein 2 antibody; GBP-2 antibody; HuGBP-2 antibody; Guanine nucleotide-binding protein 2 antibody; Interferon-induced guanylate-binding protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Guanylate-binding protein 2 protein (100-259AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，GBP2 Antibody (CSB-PA009298LA01HU)，的标记方式是Non-conjugated。对于GBP2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA009298LB01HU GBP2 Antibody, HRP conjugated ELISA
    FITC CSB-PA009298LC01HU GBP2 Antibody, FITC conjugated
    Biotin CSB-PA009298LD01HU GBP2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.
  • 基因功能参考文献：
    1. Study presents the first demonstration that GBP2 inhibits mitochondrial fission and cell metastasis in breast cancer cells both in vitro and in vivo. PMID: 29072687
    2. Low GBP2 expression is associated with metastasis in breast cancer. PMID: 23001506
    3. Downregulation of MIR-433 is associated with myeloproliferative neoplasms. PMID: 22864358
    4. The in vivo localization of GBP-2 at cellular membranes is regulated by isoprenylation and dimerization. PMID: 21151871
    5. Guanylate-binding protein 2 mRNA in peripheral blood leukocytes may have a role in acute cellular rejection after liver transplantation PMID: 19912588
    6. Sky1p utilizes the same docking groove to bind yeast SR-like protein Gbp2p and phosphorylates all three serines present in a contiguous RS dipeptide stretch PMID: 17517895
    7. GBP-2 is regulated by p53 and may have a role in esophageal squamous cell carcinomas PMID: 19003964

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus membrane. Membrane; Lipid-anchor.
  • 蛋白家族：
    TRAFAC class dynamin-like GTPase superfamily, GB1/RHD3-type GTPase family, GB1 subfamily
  • 数据库链接：

    HGNC: 4183

    OMIM: 600412

    KEGG: hsa:2634

    STRING: 9606.ENSP00000359497

    UniGene: Hs.386567