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GCSAM Antibody

  • 货号：
    CSB-PA072040
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA072040(GCSAM Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA072040(GCSAM Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q8N6F7
  • 基因名：
    GCSAM
  • 别名：
    GCAT2 antibody; Gcet antibody; GCET2 germinal center expressed transcript 2 antibody; GCET2 germinal centre expressed transcript 2 antibody; Gcsam antibody; GCSAM_HUMAN antibody; Germinal center associated lymphoma antibody; Germinal center associated lymphoma protein antibody; Germinal center B cell associated protein 2 antibody; Germinal center B-cell-expressed transcript 2 protein antibody; Germinal center expressed transcript 2 antibody; Germinal center-associated lymphoma protein antibody; Germinal center-associated signaling and motility protein antibody; Germinal centre associated lymphoma antibody; Germinal centre associated lymphoma protein antibody; Germinal centre B cell associated protein 2 antibody; Germinal centre expressed transcript 2 antibody; hGAL antibody; M17 antibody; M17 L antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human GCSAM
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.
  • 基因功能参考文献：
    1. Diagnostic Utility of the Germinal Center-associated Markers GCET1, HGAL, and LMO2 in Hematolymphoid Neoplasms. PMID: 25203428
    2. These findings further elucidate the growing and complex role of HGAL in B-cell biology and suggest that membrane-bound and cytoplasmic HGAL protein differently regulates distinct biological processes. PMID: 25381061
    3. HGAL and LMO2 may be useful adjuncts in the identification of follicular lymphoma of the nongastric gastrointestinal tract. PMID: 22914613
    4. the germinal centre protein human germinal centre-associated lymphoma regulates B-cell receptor signalling in B-lymphocytes which, without appropriate control, may lead to B-cell lymphoproliferation. PMID: 23299888
    5. HGAL/GCET2 protein expression may function as a marker for germinal center B-cell type diffuse large B-cell lymphoma. PMID: 22743653
    6. Immunostaining for HGAL was more frequently positive than that for BCL6 and CD10 in follicular lymphomas PMID: 21988858
    7. Data suggest that both HGAL and LMO2 are directly regulated by the transcription repressor PRDM1--overexpression of PRDM1 down-regulates HGAL and LMO2; PRDM1 directly binds to promoters of both HGAL and LMO2 and represses genetic transcription. PMID: 21722313
    8. necessary for germinal center maintenance and confining B-cells to the germinal center microenvironment PMID: 21475040
    9. show that HGAL increases the binding of myosin to F-actin and inhibits the ability of myosin to translocate actin by reducing the maximal velocity of myosin head/actin movement PMID: 21447067
    10. HGAL is sensitive and specific marker for detecting follicular lymphoma in nodal and extranodal sites PMID: 21502424
    11. molecular mechanism underlying the inhibitory effects of germinal center-specific HGAL protein on the motility of GC-derived lymphoma cells PMID: 20844236
    12. Our results show that HGAL and LMO2 are sensitive markers for follicular lymphoma diagnosis. PMID: 20697248
    13. Study confirms and validates findings of a correlation between HGAL expression and outcome in classical HL. PMID: 19883310
    14. gene is induced by IL4 and expression strongly predicts survival in diffuse large B-cell lymphoma PMID: 12509382
    15. Results report the cloning of germinal center B-cell expressed transcripts 1 and 2 (GCET1 and 2), and show that both are expressed in follicular lymphoma and diffuse large B-cell lymphoma with germinal center B-cell differentiation PMID: 12819018
    16. The restricted expression and germinal center specificity of HGAL protein suggest that it may have an important role in the diagnosis of specific lymphomas PMID: 15677569
    17. HGAL is involved in negative regulation of lymphocyte migration, thus constraining lymphocytes to the germinal center PMID: 17823310
    18. The correlation of HGAL expression with the germinal center B-cell phenotype demonstrates the role of this marker in the classification of cutaneous large B-cell lymphomas PMID: 18264083
    19. results report the cloning of HGAL, a germinal center its expression pattern in normal tissues and hematologic malignancies, its induction by IL4, and the prognostic significance of its expression in predicting survival in diffuse large B-cell lymphoma PMID: 12509382

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  • 亚细胞定位：
    Cytoplasm. Cell membrane. Note=It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6.
  • 组织特异性：
    Expressed in diffuse large B-cell lymphoma (DLBCL) and several germinal center (GC)-like lymphoma cell lines (at protein level). Highly expressed in normal GC lymphocytes and GC-derived malignancies. Expressed in thymus and spleen.
  • 数据库链接：

    HGNC: 20253

    OMIM: 607792

    KEGG: hsa:257144

    STRING: 9606.ENSP00000419485

    UniGene: Hs.49614