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  4. GFM2 Antibody

GFM2 Antibody

  • 货号：
    CSB-PA070018
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q969S9
  • 基因名：
    GFM2
  • 别名：
    GFM2 antibody; EFG2 antibody; MSTP027 antibody; Ribosome-releasing factor 2 antibody; mitochondrial antibody; RRF2mt antibody; Elongation factor G 2 antibody; mitochondrial antibody; EF-G2mt antibody; mEF-G 2 antibody; Elongation factor G2 antibody; hEFG2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human EF-G2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
  • 基因功能参考文献：
    1. GFM2 mutations could be causative of a phenotype of Leigh syndrome with arthrogryposis multiplex congenita. PMID: 26016410
    2. These findings constitute the first reported phenotype associated with SNPs in the EF-G2mt gene and implicate the human EF-G2mt gene as a pharmacogenetic candidate gene for statin toxicity in humans PMID: 22719265
    3. Myoblasts isolated from the MELAS patients show A3243G mutation in tRNALeu(UUR) produces a severe respiratory chain deficiency and this phenotype can be partially suppressed by overexpression of EFTu and EFG2. PMID: 18753147
    4. EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis. PMID: 19716793
  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-G/EF-2 subfamily
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 29682

    OMIM: 606544

    KEGG: hsa:84340

    STRING: 9606.ENSP00000296805

    UniGene: Hs.277154