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GFRA3 Antibody

  • 货号：
    CSB-PA009381LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA009381LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA009381LA01HU at dilution of 1:100
    • Immunofluorescent analysis of PC-3 cells using CSB-PA009381LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GFRA3 Polyclonal antibody
  • Uniprot No.：
    O60609
  • 基因名：
    GFRA3
  • 别名：
    GDNF family receptor alpha 3 antibody; GDNF family receptor alpha-3 antibody; GDNF receptor alpha-3 antibody; GDNFR-alpha-3 antibody; GDNFR3 antibody; GFR-alpha-3 antibody; GFRA3 antibody; GFRA3_HUMAN antibody; Glial cell line derived neurotrophic factor receptor alpha 3 antibody; GPI linked receptor antibody; OTTHUMP00000159486 antibody; OTTHUMP00000224020 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human GDNF family receptor alpha-3 protein (32-236AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，GFRA3 Antibody (CSB-PA009381LA01HU)，的标记方式是Non-conjugated。对于GFRA3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA009381LB01HU GFRA3 Antibody, HRP conjugated ELISA
    FITC CSB-PA009381LC01HU GFRA3 Antibody, FITC conjugated
    Biotin CSB-PA009381LD01HU GFRA3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.
  • 基因功能参考文献：
    1. increased GFRalpha3 expression is significantly correlated with poor prognosis of patients with urothelial carcinoma PMID: 28651425
    2. Mir-34a directly regulates GFRA3 via its coding region.GFRA3 is crucial for breast cancer growth. PMID: 28356515
    3. The GFRA3 promoter region showed marked hypermethylation in almost all tumors, and its correlation with survival and other clinicopathological parameters may have important prognostic significance. PMID: 26984265
    4. The lack of expression of the RET/GFRA system could be related to the cell mislocation and deregulated growth of craniopharyngiomas. PMID: 22031517
    5. Artemin and GFRalpha3 expressions may play an important role in perineural invasion of pancreatic carcinoma. PMID: 19304517
    6. 1.92 A crystal structure of the complex formed between ARTN and its receptor GFRalpha3 was reported. PMID: 16765900
    7. In the human digestive and reproductive systems, a subset of epithelial cells exhibited GFRalpha3- and RET-like staining, suggesting co-localization. PMID: 16773224

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    GDNFR family
  • 组织特异性：
    Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non
  • 数据库链接：

    HGNC: 4245

    OMIM: 605710

    KEGG: hsa:2676

    STRING: 9606.ENSP00000274721

    UniGene: Hs.58042