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GIMAP4 Antibody

  • 货号：
    CSB-PA002681
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of RAW264.7 cells using GIMAP4 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9NUV9
  • 基因名：
    GIMAP4
  • 别名：
    FLJ11110 antibody; GIMA4_HUMAN antibody; Gimap4 antibody; GTPase IMAP family member 4 antibody; GTPase IMAP family member 4 antibody; hIAN1 antibody; HIMAP4 antibody; Human immune associated nucleotide 1 antibody; IAN-1 antibody; IAN1 antibody; IMAP4 antibody; Immunity associated nucleotide 1 protein antibody; Immunity associated protein 4 antibody; Immunity-associated nucleotide 1 protein antibody; Immunity-associated protein 4 antibody; MSTP062 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human GIMAP4.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    During thymocyte development, may play a role in the regulation of apoptosis. GTPase which exhibits a higher affinity for GDP than for GTP.
  • 基因功能参考文献：
    1. GIMAP4 regulates secretion of cytokines in early differentiating human CD4(+) T helper lymphocytes and in particular the secretion of interferon-gamma also affecting its downstream targets. PMID: 25287446
    2. Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet's disease PMID: 23041938
    3. molecular and genetic properties; expression in resting T- and B-cells and decreased expression during lymphocyte activation PMID: 11964296
    4. GIMAP1 and GIMAP4 genes are up-regulated by IL-12 and other Th1 differentiation-inducing cytokines in cells induced to differentiate toward Th1 lineage and down-regulated by IL-4 in cells induced to Th2. PMID: 18701445
  • 亚细胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, AIG1/Toc34/Toc159-like paraseptin GTPase family, IAN subfamily
  • 组织特异性：
    Highly expressed in spleen and peripheral blood leukocytes that contain mostly T- and B-lymphocytes. Expressed specifically in resting T- and B-lymphocytes and expression significantly decreases during B- or T-lymphocyte activation. Expressed at lower lev
  • 数据库链接：

    HGNC: 21872

    OMIM: 608087

    KEGG: hsa:55303

    STRING: 9606.ENSP00000255945

    UniGene: Hs.647101