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GINS1 Antibody

  • 货号：
    CSB-PA377075
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA377075(GINS1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA377075(GINS1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q14691
  • 基因名：
    GINS1
  • 别名：
    DNA replication complex GINS protein PSF1 antibody; GINS complex subunit 1 (Psf1 homolog) antibody; GINS complex subunit 1 antibody; GINS1 antibody; partner of sld five-1 antibody; partner of sld5 antibody; PSF1 homolog antibody; PSF1_HUMAN antibody; RP4-691N24.2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human GINS1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:15-1:50
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.
  • 基因功能参考文献：
    1. The s show that GINS is a compact tetramer in solution as observed in crystal structures, but also forms a double-tetrameric population, detectable by electron microscopy. PMID: 28071757
    2. Autosomal recessive, partial GINS1 deficiency impairs DNA replication and underlies intra-uterine (and postnatal) growth retardation, chronic neutropenia, and NK cell deficiency. PMID: 28414293
    3. PSF1 mRNA expression was an independent factor associated with prognosis of colorectal cancer. PMID: 21713706
    4. These results suggest that PSF1 over-expression is specifically involved in breast cancer cell growth. PMID: 20825491
    5. Findings implicate PSF1 in tumorigenesis and offer initial evidence of its potential as a theranostic target. PMID: 20103637
    6. expression of mammalian GINS is regulated by 17beta-Estradiol-stimulated estrogen receptor alpha, and PSF3 acts as a gene responsive to transcription factor E2F1 PMID: 17127213
    7. the C-terminal domain of Psf1 does not contribute to the stability of the GINS complex but is crucial for chromatin binding and replication activity PMID: 17417653

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  • 亚细胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    GINS1/PSF1 family
  • 数据库链接：

    HGNC: 28980

    OMIM: 610608

    KEGG: hsa:9837

    STRING: 9606.ENSP00000262460

    UniGene: Hs.658464