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GINS2 Antibody

  • 货号：
    CSB-PA896481ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA896481ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA896481ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GINS2 Polyclonal antibody
  • Uniprot No.：
    Q9Y248
  • 基因名：
    GINS2
  • 别名：
    DNA replication complex GINS protein PSF2 antibody; GINS complex subunit 2 (Psf2 homolog) antibody; GINS complex subunit 2 antibody; gins2 antibody; HSPC037 antibody; Pfs2 antibody; PSF2 antibody; PSF2_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human DNA replication complex GINS protein PSF2 protein (1-185AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.
  • 基因功能参考文献：
    1. The s show that GINS is a compact tetramer in solution as observed in crystal structures, but also forms a double-tetrameric population, detectable by electron microscopy. PMID: 28071757
    2. GINS2 is overexpressed in cervical cancer.GINS2 is a novel indicator of pelvic lymph node metastasis in cervical cancer. PMID: 28405687
    3. silencing of GINS2 in triple negative breast cancer cells caused dramatic decrease of matrix metalloproteinase-9 (MMP9). PMID: 27829549
    4. High GINS2 transcript level is associated with endocrine therapy resistance in beast cancer. PMID: 25348432
    5. On the contrary, after HL60 cells were infected by recombinant adenovirus vector which contained GINS2 gene, we observed that over-expression of GINS2 could promote HL-60 cell proliferation. PMID: 24273454
    6. GINS2 plays an important role in apoptosis and may function via the p38MAPK signaling pathway. PMID: 23589040
    7. Data show that using a 200-nt primed circular DNA substrate, the combined action of DNA polymerase epsilon and the Cdc45/Mcm2-7/GINS (CMG complex) leads to the formation of products >10 kb in length. PMID: 22474384
    8. Data suggest that GINS2 to be associated with the aggressive characteristics of a subgroup of breast cancers in vivo. PMID: 21082043

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  • 亚细胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    GINS2/PSF2 family
  • 数据库链接：

    HGNC: 24575

    OMIM: 610609

    KEGG: hsa:51659

    STRING: 9606.ENSP00000253462

    UniGene: Hs.433180