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GINS3 Antibody

  • 中文名称：
    GINS3多克隆抗体
  • 货号：
    CSB-PA009432GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BRX5
  • 基因名：
    GINS3
  • 别名：
    DNA replication complex GINS protein PSF3 antibody; GINS complex subunit 3 antibody; Gins3 antibody; PSF3 homolog antibody; PSF3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human GINS3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.
  • 基因功能参考文献：
    1. The s show that GINS is a compact tetramer in solution as observed in crystal structures, but also forms a double-tetrameric population, detectable by electron microscopy. PMID: 28071757
    2. expression in primary lung adenocarcinoma plays an important role in disease progression and is a prognostic indicator PMID: 27005977
    3. Psf3 expression was strongly correlated with tumor progression in non-small-cell lung cancer PMID: 26291987
    4. Two downregulated genes, NDRG4 and GINS3, have been located in a genomic interval associated with cardiac repolarization in published GWASs and zebra fish knockout models PMID: 25520251
    5. PSF3 expression plays an important role in the progression of colorectal cancer and acts as a factor significantly affecting the prognosis of patients. PMID: 25403684
    6. a prognostic biomarker in lung adenocarcinoma PMID: 23127337
    7. These results suggest that PSF3 is a potential biomarker for diagnosis of progression in colon cancer and could PMID: 20059967
    8. expression of mammalian GINS is regulated by 17beta-Estradiol-stimulated estrogen receptor alpha, and PSF3 acts as a gene responsive to transcription factor E2F1 PMID: 17127213
    9. This sensitized zebrafish screen identified 15 novel myocardial repolarization genes. Among these genes is GINS3, the human ortholog of which is a major locus in 2 concurrent human genome-wide association studies of QT interval. PMID: 19652097
    10. This paper describes work done in Saccharomyces cerevisiae. PMID: 12730134
    11. This paper describes work done in Schizosaccharomyces pombe. PMID: 16990792

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  • 亚细胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    GINS3/PSF3 family
  • 数据库链接：

    HGNC: 25851

    OMIM: 610610

    KEGG: hsa:64785

    UniGene: Hs.47125