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GLMN Antibody

  • 货号：
    CSB-PA170354
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA170354(GLMN Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA170354(GLMN Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q92990
  • 基因名：
    GLMN
  • 别名：
    FAP antibody; FAP48 antibody; FAP68 antibody; FK506 binding protein associated protein antibody; FK506-binding protein-associated protein antibody; FKBP associated protein antibody; FKBP-associated protein antibody; FKBP-associated protein, 48-KD antibody; FKBP-associated protein, 68-KD antibody; FKBPAP antibody; GLML antibody; Glmn antibody; GLMN_HUMAN antibody; Glomulin antibody; glomulin, FKBP associated protein antibody; GVM antibody; VMGLOM antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human GLMN
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes. Inhibits E3 ubiquitin ligase activity by binding to RBX1 (via RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34. Inhibits RBX1-mediated neddylation of CUL1. Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels. Essential for normal development of the vasculature. Contributes to the regulation of RPS6KB1 phosphorylation.
  • 基因功能参考文献：
    1. Our report contributes to document the possible association between the c.395-1G>C mutation of GLMN gene and glomuvenous malformations. PMID: 24961656
    2. FAP48 adipocyte expression plays a key role in HIV-associated lipodystrophy. PMID: 22678819
    3. These data identify glomulin as a permissivity factor for VACV infection and as a potential therapeutic target for inhibition of vaccinia virus (VACV) infection. PMID: 22280104
    4. The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin-1 RING ligase-mediated turnover of Fbw7. PMID: 22405651
    5. A novel GLMN mutation is described in an Italian family with glomuvenous malformations in which some members present with the less commonly observed phenotype of solitary lesions. PMID: 22092580
    6. Describes the characterizations of 14 different mutations in the glomulin gene in patients with glomuvenous malformations. PMID: 11845407
    7. FAP48-FKBP complexes increase IL2 production PMID: 12604780

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  • 相关疾病：
    Glomuvenous malformations (GVMs)
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 14373

    OMIM: 138000

    KEGG: hsa:11146

    STRING: 9606.ENSP00000359385

    UniGene: Hs.49105