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GLRX3 Antibody

  • 货号：
    CSB-PA009523GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O76003
  • 基因名：
    GLRX3
  • 别名：
    glrx3 antibody; GLRX3_HUMAN antibody; GLRX4 antibody; Glutaredoxin 3 antibody; Glutaredoxin 4 antibody; Glutaredoxin-3 antibody; GRX3 antibody; GRX4 antibody; PICOT antibody; PKC interacting cousin of thioredoxin antibody; PKC theta interacting protein antibody; PKC-interacting cousin of thioredoxin antibody; PKC-theta-interacting protein antibody; PKCq interacting protein antibody; PKCq-interacting protein antibody; Thioredoxin like protein 2 antibody; Thioredoxin-like protein 2 antibody; TXNL2 antibody; TXNL3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human GLRX3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.
  • 基因功能参考文献：
    1. The findings suggested the vital roles of GLRX3 in OSCC progression through its relationship with EMT progression, and these data also suggest that a strategy of blocking ROS to enhance the activity of GLRX3 knockdown warrants further attention in the treatment of OSCC. PMID: 29397791
    2. GLRX3 might be an oncoprotein in nasopharyngeal carcinoma PMID: 27203742
    3. The Glrx3.BolA is a [2Fe-2S] chaperone complex capable of transferring [2Fe-2S] clusters to apoproteins in human cells. PMID: 27519415
    4. apo GRX3 and apo BOLA2 form a heterotrimeric complex, composed by two BOLA2 molecules and one GRX3 molecule PMID: 26613676
    5. findings provide novel insights into the regulation of Grx3, which is crucial for cell survival against environmental insults PMID: 25975981
    6. These findings provide an advanced view of the functional role of glutaredoxin-3 in iron metabolism. PMID: 26302480
    7. These in vitro studies suggest that human GLRX3 is important for cytosolic Fe-S protein maturation. PMID: 26296460
    8. Data indicate that silencing of Grx3 in HeLa cells decreases the activities of several cytosolic Fe/S proteins, including iron-regulatory protein 1, a major component of posttranscriptional iron regulation. PMID: 23615448
    9. these data raise the possibility that the pro-apoptotic role of PICOT is actively regulated via caspase-3-mediated cleavage. PMID: 23415866
    10. the unusual [2Fe-2S]-bridging Grx-BolA interaction is conserved in higher eukaryotes and may play a role in signaling cellular iron status in humans. PMID: 22309771
    11. investigations into role of Grx3: Grx3-knockdown in HeLa cells leads to significant delay in mitotic exit and a higher percentage of binucleated cells. PMID: 21575136
    12. analysis of primary breast cancer samples demonstrated that enhanced TXNL2 expression correlated with metastasis to the lung and brain and with decreased overall patient survival PMID: 21123948
    13. Demonstrated a differential expression of PICOT in various cell types, with a predominant cytosolic staining of epithelial cells and low or undetectable levels of PICOT in the stroma. PMID: 20498481
    14. The present results show a direct correlation between PICOT expression levels and increased cell growth, both in vitro and in vivo. PMID: 20170406
    15. redox-induced dissociation of the Grx3/PICOT holo complex may be a mechanism of Grx3/PICOT activation in response to reactive oxygen and nitrogen species. PMID: 20226171
    16. Western blot analysis revealed consistent and preferential expression of Glrx3 in lung and colon cancers; results suggest that Glrx3 could take a pivotal role in colon and lung cancer cells during tumorigenesis PMID: 19797004
    17. thioredoxin-like 2 may have a role in colorectal cancer, as it is the antigen for the monoclonal antibody MC3 specific to colorectal cancer PMID: 18528843

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  • 亚细胞定位：
    Cytoplasm, cytosol. Cytoplasm, cell cortex. Cytoplasm, myofibril, sarcomere, Z line.
  • 组织特异性：
    Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine.
  • 数据库链接：

    HGNC: 15987

    OMIM: 612754

    KEGG: hsa:10539

    STRING: 9606.ENSP00000330836

    UniGene: Hs.42644