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GMEB1 Antibody

  • 货号：
    CSB-PA896751LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GMEB1 Polyclonal antibody
  • Uniprot No.：
    Q9Y692
  • 基因名：
    GMEB1
  • 别名：
    DNA binding protein p96PIF antibody; DNA-binding protein p96PIF antibody; Glucocorticoid modulatory element binding protein 1 antibody; Glucocorticoid modulatory element-binding protein 1 antibody; GMEB 1 antibody; GMEB-1 antibody; Gmeb1 antibody; GMEB1_HUMAN antibody; P96PIF antibody; Parvovirus initiation factor p96 antibody; PIF 96 antibody; PIF p96 antibody; PIF96 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Glucocorticoid modulatory element-binding protein 1 protein (2-245AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，GMEB1 Antibody (CSB-PA896751LA01HU)，的标记方式是Non-conjugated。对于GMEB1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA896751LB01HU GMEB1 Antibody, HRP conjugated ELISA
    FITC CSB-PA896751LC01HU GMEB1 Antibody, FITC conjugated
    Biotin CSB-PA896751LD01HU GMEB1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.
  • 基因功能参考文献：
    1. consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters PMID: 11743720
    2. 1.55 A resolution crystal structure of a central portion of GMEB1, encompassing its SAND domain PMID: 12702733
    3. GMEB1 is capable of binding to the prodomain of caspase-2; findings indicated that GMEB1 might be an endogenous inhibitory protein that selectively interacts with prodomain of caspase-2 to disrupt the autoactivation PMID: 15555560
    4. GMEB1 is an endogenous regulator that selectively binds to initiator procaspases and inhibits caspase-induced apoptosis PMID: 16497673
    5. GMEB1 effectively attenuated caspase activation and apoptosis caused by these stresses in human neuroblastoma SK-N-MC cells, indicating that it functions as a potent inhibitor of caspase activation and apoptosis in response to oxidative stress. PMID: 18455874

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Note=May be also cytoplasmic.
  • 数据库链接：

    HGNC: 4370

    OMIM: 604409

    KEGG: hsa:10691

    STRING: 9606.ENSP00000294409

    UniGene: Hs.632373