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GNG7 Antibody

  • 货号：
    CSB-PA009619LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of MCF-7 cells with CSB-PA009619LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GNG7 Polyclonal antibody
  • Uniprot No.：
    O60262
  • 基因名：
  • 别名：
    GNG7 antibody; GNGT7 antibody; Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 protein (2-65AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，GNG7 Antibody (CSB-PA009619LA01HU)，的标记方式是Non-conjugated。对于GNG7 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA009619LB01HU GNG7 Antibody, HRP conjugated ELISA
    FITC CSB-PA009619LC01HU GNG7 Antibody, FITC conjugated
    Biotin CSB-PA009619LD01HU GNG7 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum.
  • 基因功能参考文献：
    1. GNG7 is a highly specific promoter methylated gene associated with head and neck cancer. PMID: 23403885
    2. Loss of GNG7 protein expression is a frequent event in head and neck cancer with hypermethylation of the promoter region of GNG7 being probably the mechanism for the observed inactivation. PMID: 22183866
    3. Reduced expression of G-gamma 7 is associated with the histological grade of EHCC and may prove to be a useful marker for predicting the prognosis of human EHCC. PMID: 20543539
    4. GNG7 suppression represents a new prognostic indicator in cases of oesophageal cancer. PMID: 18219292
  • 亚细胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    G protein gamma family
  • 组织特异性：
    Expressed in a variety of tissues. Down-regulated in pancreatic and esophageal cancer.
  • 数据库链接：

    HGNC: 4410

    OMIM: 604430

    KEGG: hsa:2788

    STRING: 9606.ENSP00000371594

    UniGene: Hs.515544